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The Effect of Nanomaterials on DNA Methylation: A Review

2023-06-17Journal article Open access
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dc.contributor.authorValente, Ana
dc.contributor.authorVieira, Luís
dc.contributor.authorSilva, Maria João
dc.contributor.authorVentura, Célia
dc.date.accessioned2023-10-06T13:39:31Z
dc.date.available2023-10-06T13:39:31Z
dc.date.issued2023-06-17
dc.descriptionReviewpt_PT
dc.descriptionThis article belongs to the Special Issue Interaction of Nanomaterials with Biological Systems: In Vitro and In Vivo Studies.pt_PT
dc.description.abstractDNA methylation is an epigenetic mechanism that involves the addition of a methyl group to a cytosine residue in CpG dinucleotides, which are particularly abundant in gene promoter regions. Several studies have highlighted the role that modifications of DNA methylation may have on the adverse health effects caused by exposure to environmental toxicants. One group of xenobiotics that is increasingly present in our daily lives are nanomaterials, whose unique physicochemical properties make them interesting for a large number of industrial and biomedical applications. Their widespread use has raised concerns about human exposure, and several toxicological studies have been performed, although the studies focusing on nanomaterials’ effect on DNA methylation are still limited. The aim of this review is to investigate the possible impact of nanomaterials on DNA methylation. From the 70 studies found eligible for data analysis, the majority were in vitro, with about half using cell models related to the lungs. Among the in vivo studies, several animal models were used, but most were mice models. Only two studies were performed on human exposed populations. Global DNA methylation analyses was the most frequently applied approach. Although no trend towards hypo- or hyper-methylation could be observed, the importance of this epigenetic mechanism in the molecular response to nanomaterials is evident. Furthermore, methylation analysis of target genes and, particularly, the application of comprehensive DNA methylation analysis techniques, such as genome-wide sequencing, allowed identifying differentially methylated genes after nanomaterial exposure and affected molecular pathways, contributing to the understanding of their possible adverse health effects.pt_PT
dc.description.sponsorshipThis research received funding from the Portuguese Foundation for Science and Technology (FCT/MCTES) under the project ToxApp4NanoCELFI (PTDC/SAUPUB/32587/2017) and projects UIDB/00009/2020 and UIDP/00009/2020 (ToxOmics).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNanomaterials (Basel). 2023 Jun 17;13(12):1880. doi: 10.3390/nano13121880. Reviewpt_PT
dc.identifier.doi10.3390/nano13121880pt_PT
dc.identifier.issn2079-4991
dc.identifier.urihttp://hdl.handle.net/10400.18/8669
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationPTDC/SAUPUB/32587/2017pt_PT
dc.relationCentre for Toxicogenomics and Human Health
dc.relationCentre for Toxicogenomics and Human Health
dc.relation.publisherversionhttps://www.mdpi.com/2079-4991/13/12/1880pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectDNA Hypermethylationpt_PT
dc.subjectDNA Hypomethylationpt_PT
dc.subjectMethylationpt_PT
dc.subjectNanotoxicologypt_PT
dc.subjectGenome Methylationpt_PT
dc.subjectEpigeneticspt_PT
dc.subjectNanomaterialpt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleThe Effect of Nanomaterials on DNA Methylation: A Reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Toxicogenomics and Human Health
oaire.awardTitleCentre for Toxicogenomics and Human Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00009%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00009%2F2020/PT
oaire.citation.issue12pt_PT
oaire.citation.startPage1880pt_PT
oaire.citation.titleNanomaterialspt_PT
oaire.citation.volume13pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSilva
person.familyNameVentura
person.givenNameMaria Joao
person.givenNameCélia
person.identifier2056460
person.identifier.ciencia-id7710-643D-97A3
person.identifier.ciencia-id6116-89BA-C617
person.identifier.orcid0000-0002-6060-0716
person.identifier.orcid0000-0002-0637-2222
person.identifier.scopus-author-id55944437600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com política editorial da revistapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa7763685-7c34-468d-b958-9dd0aca66db4
relation.isAuthorOfPublicationfa89f42b-12a4-47bd-a4fb-0f65cbc06885
relation.isAuthorOfPublication.latestForDiscoverya7763685-7c34-468d-b958-9dd0aca66db4
relation.isProjectOfPublicationa438b9d1-8a6a-4c90-a13b-7ccf34071451
relation.isProjectOfPublication8836ec79-2300-487a-97ad-75e98cfabcfa
relation.isProjectOfPublication.latestForDiscovery8836ec79-2300-487a-97ad-75e98cfabcfa

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