Publication
Impact of national influenza vaccination strategy in severe influenza outcomes among the high-risk Portuguese population
| dc.contributor.author | Machado, Ausenda | |
| dc.contributor.author | Kislaya, Irina | |
| dc.contributor.author | Larrauri, Amparo | |
| dc.contributor.author | Matias Dias, Carlos | |
| dc.contributor.author | Nunes, Baltazar | |
| dc.date.accessioned | 2020-04-27T06:33:48Z | |
| dc.date.available | 2020-04-27T06:33:48Z | |
| dc.date.issued | 2019-12-16 | |
| dc.description.abstract | All aged individuals with a chronic condition and those with 65 and more years are at increased risk of severe influenza post-infection complications. There is limited research on cases averted by the yearly vaccination programs in high-risk individuals. The objective was to estimate the impact of trivalent seasonal influenza vaccination on averted hospitalizations and death among the high-risk population in Portugal. The impact of trivalent seasonal influenza vaccination was estimated using vaccine coverage, vaccine effectiveness and the number of influenza-related hospitalizations and deaths. The number of averted events (NAE), prevented fraction (PF) and number needed to vaccinate (NVN) were estimated for seasons 2014/15 to 2016/17. The vaccination strategy averted on average approximately 1833 hospitalizations and 383 deaths per season. Highest NAE was observed in the ≥65 years population (85% of hospitalizations and 95% deaths) and in the 2016/17 season (1957 hospitalizations and 439 deaths). On average, seasonal vaccination prevented 21% of hospitalizations in the population aged 65 and more, and 18.5% in the population with chronic conditions. The vaccination also prevented 29% and 19.5% of deaths in each group of the high-risk population. It would be needed to vaccinate 3360 high-risk individuals, to prevent one hospitalization and 60,471 high-risk individuals to prevent one death. The yearly influenza vaccination campaigns had a sustained positive benefit for the high-risk population, reducing hospitalizations and deaths. These results can support public health plans toward increased vaccine coverage in high-risk groups. | pt_PT |
| dc.description.sponsorship | Activities related to individuals aged 65 and more years were supported by European Commission Horizon 2020 programme [grant agreement No 634446]. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | BMC Public Health. 2019 Dec 16;19(1):1690. doi: 10.1186/s12889-019-7958-8 | pt_PT |
| dc.identifier.doi | 10.1186/s12889-019-7958-8 | pt_PT |
| dc.identifier.issn | 1471-2458 | |
| dc.identifier.uri | http://hdl.handle.net/10400.18/6523 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Springer Nature/ BMC | pt_PT |
| dc.relation | I-MOVE+ Integrated Monitoring of Vaccines Effects in Europe: a platform to measure and compare effectiveness and impact of influenza and pneumococcal vaccines and vaccination strategies in the elderly | |
| dc.relation.publisherversion | https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-019-7958-8 | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Influenza Vaccine | pt_PT |
| dc.subject | Vacina Antigripal | pt_PT |
| dc.subject | Influenza Vaccination Impact | pt_PT |
| dc.subject | Hospitalization | pt_PT |
| dc.subject | Determinantes da Saúde e da Doença | pt_PT |
| dc.subject | Cuidados de Saúde | pt_PT |
| dc.title | Impact of national influenza vaccination strategy in severe influenza outcomes among the high-risk Portuguese population | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | I-MOVE+ Integrated Monitoring of Vaccines Effects in Europe: a platform to measure and compare effectiveness and impact of influenza and pneumococcal vaccines and vaccination strategies in the elderly | |
| oaire.awardURI | info:eu-repo/grantAgreement/EC/H2020/634446/EU | |
| oaire.citation.issue | 1 | pt_PT |
| oaire.citation.startPage | 1690 | pt_PT |
| oaire.citation.title | BMC Public Health | pt_PT |
| oaire.citation.volume | 19 | pt_PT |
| oaire.fundingStream | H2020 | |
| project.funder.identifier | http://doi.org/10.13039/501100008530 | |
| project.funder.name | European Commission | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isProjectOfPublication | ccfd73a6-6f3c-4702-956c-544973bca97d | |
| relation.isProjectOfPublication.latestForDiscovery | ccfd73a6-6f3c-4702-956c-544973bca97d |