Repository logo
 
Publication

Associations Between Extreme Temperatures and Cardiovascular Cause-Specific Mortality: Results From 27 Countries

2022-12-12Journal article Open access
Simple item page
dc.contributor.authorAlahmad, Barrak
dc.contributor.authorKhraishah, Haitham
dc.contributor.authorRoyé, Dominic
dc.contributor.authorVicedo-Cabrera, Ana Maria
dc.contributor.authorGuo, Yuming
dc.contributor.authorPapatheodorou, Stefania I.
dc.contributor.authorAchilleos, Souzana
dc.contributor.authorAcquaotta, Fiorella
dc.contributor.authorArmstrong, Ben
dc.contributor.authorBell, Michelle L.
dc.contributor.authorPan, Shih-Chun
dc.contributor.authorCoelho, Micheline de Sousa Zanotti Stagliorio
dc.contributor.authorColistro, Valentina
dc.contributor.authorDang, Tran Ngoc
dc.contributor.authorDung, Do-Van
dc.contributor.authorDe' Donato, Francesca K.
dc.contributor.authorEntezari, Alireza
dc.contributor.authorGuo, Yue-Liang Leon
dc.contributor.authorHashizume, Masahiro
dc.contributor.authorHonda, Yasushi
dc.contributor.authorIndermitte, Ene
dc.contributor.authorÍñiguez, Carmen
dc.contributor.authorJaakkola, Jouni J.K.
dc.contributor.authorKim, Ho
dc.contributor.authorLavigne, Eric
dc.contributor.authorLee, Whanhee
dc.contributor.authorLi, Shanshan
dc.contributor.authorMadureira, Joana
dc.contributor.authorMayvaneh, Fatemeh
dc.contributor.authorOrru, Hans
dc.contributor.authorOvercenco, Ala Vladimir
dc.contributor.authorRagettli, Martina S.
dc.contributor.authorRyti, Niilo R.I.
dc.contributor.authorSaldiva, Paulo Hilario Nascimento
dc.contributor.authorScovronick, Noah
dc.contributor.authorSeposo, Xerxes
dc.contributor.authorSera, Francesco
dc.contributor.authorSilva, Susana
dc.contributor.authorStafoggia, Massimo
dc.contributor.authorTobias, Aurelio
dc.contributor.authorGarshick, Eric
dc.contributor.authorBernstein, Aaron S.
dc.contributor.authorZanobetti, Antonella
dc.contributor.authorSchwartz, Joel D.
dc.contributor.authorGasparrini, Antonio
dc.contributor.authorKoutrakis, Petros
dc.date.accessioned2023-01-25T13:08:18Z
dc.date.available2023-01-25T13:08:18Z
dc.date.issued2022-12-12
dc.description.abstractBackground: Cardiovascular disease is the leading cause of death worldwide. Existing studies on the association between temperatures and cardiovascular deaths have been limited in geographic zones and have generally considered associations with total cardiovascular deaths rather than cause-specific cardiovascular deaths. Methods: We used unified data collection protocols within the Multi-Country Multi-City Collaborative Network to assemble a database of daily counts of specific cardiovascular causes of death from 567 cities in 27 countries across 5 continents in overlapping periods ranging from 1979 to 2019. City-specific daily ambient temperatures were obtained from weather stations and climate reanalysis models. To investigate cardiovascular mortality associations with extreme hot and cold temperatures, we fit case-crossover models in each city and then used a mixed-effects meta-analytic framework to pool individual city estimates. Extreme temperature percentiles were compared with the minimum mortality temperature in each location. Excess deaths were calculated for a range of extreme temperature days. Results: The analyses included deaths from any cardiovascular cause (32 154 935), ischemic heart disease (11 745 880), stroke (9 351 312), heart failure (3 673 723), and arrhythmia (670 859). At extreme temperature percentiles, heat (99th percentile) and cold (1st percentile) were associated with higher risk of dying from any cardiovascular cause, ischemic heart disease, stroke, and heart failure as compared to the minimum mortality temperature, which is the temperature associated with least mortality. Across a range of extreme temperatures, hot days (above 97.5th percentile) and cold days (below 2.5th percentile) accounted for 2.2 (95% empirical CI [eCI], 2.1–2.3) and 9.1 (95% eCI, 8.9–9.2) excess deaths for every 1000 cardiovascular deaths, respectively. Heart failure was associated with the highest excess deaths proportion from extreme hot and cold days with 2.6 (95% eCI, 2.4–2.8) and 12.8 (95% eCI, 12.2–13.1) for every 1000 heart failure deaths, respectively. Conclusions: Across a large, multinational sample, exposure to extreme hot and cold temperatures was associated with a greater risk of mortality from multiple common cardiovascular conditions. The intersections between extreme temperatures and cardiovascular health need to be thoroughly characterized in the present day—and especially under a changing climate.pt_PT
dc.description.abstractClinical Perspective_ What Is New?: This study provided evidence from what we believe is the largest multinational dataset ever assembled on cardiovascular outcomes and environmental exposures; Extreme hot and cold temperatures were associated with increased risk of death from any cardiovascular cause, ischemic heart disease, stroke, and heart failure; For every 1000 cardiovascular deaths, 2 and 9 excess deaths were attributed to extreme hot and cold days, respectively. _ What Are the Clinical Implications?: Extreme temperatures from a warming planet may become emerging priorities for public health and preventative cardiology; The findings of this study should prompt professional cardiology societies to commission scientific statements on the intersections of extreme temperature exposure and cardiovascular health.pt_PT
dc.description.sponsorshipThis study was supported by the Kuwait Foundation for the Advancement of Science (CB21-63BO-01); the US Environmental Protection Agency (RD-835872); Harvard Chan National Institute of Environmental Health Sciences Center for Environmental Health (P01ES009825); the UK Medical Research Council (MR/R013349/1); the UK Natural Environment Research Council (NE/R009384/1); the European Union’s Horizon 2020 Project Exhaustion (820655); the Australian National Health and Medical Research Council (APP 2000581, APP 1109193, APP 1163693); the National Institute of Environmental Health Sciences–funded HERCULES Center (P30ES019776); the MCIN/AEI/10.13039/501100011033 (grant CEX2018-000794-S); the Taiwanese Ministry of Science and Technology (MOST 109–2621-M-002–021); the Environmental Restoration and Conservation Agency, Environment Research and Technology Development Fund (JPMEERF15S11412); the São Paulo Research Foundation; and Fundação para a Ciência e a Tecnlogia (SFRH/BPD/115112/2016)pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCirculation. 2023 Jan 3;147(1):35-46. doi: 10.1161/CIRCULATIONAHA.122.061832. Epub 2022 Dec 12.pt_PT
dc.identifier.doi10.1161/CIRCULATIONAHA.122.061832pt_PT
dc.identifier.issn0009-7322
dc.identifier.urihttp://hdl.handle.net/10400.18/8457
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherLippincott Williams & Wilkins/ American Heart Associationpt_PT
dc.relationExposure to heat and air pollution in EUrope – cardiopulmonary impacts and benefits of mitigation and adaptation
dc.relationEarly life exposure to atmospheric air pollutants and potential DNA damage: Consequences on development and childhood outcomes APPEAL
dc.relation.publisherversionhttps://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.061832pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/pt_PT
dc.subjectClimate Changept_PT
dc.subjectCold Temperaturept_PT
dc.subjectHeart Failurept_PT
dc.subjectHeatpt_PT
dc.subjectHot Temperaturept_PT
dc.subjectMyocardial Ischemiapt_PT
dc.subjectStrokept_PT
dc.subjectCardiovascular Diseasept_PT
dc.subjectDeterminantes da Saúde e da Doençapt_PT
dc.titleAssociations Between Extreme Temperatures and Cardiovascular Cause-Specific Mortality: Results From 27 Countriespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleExposure to heat and air pollution in EUrope – cardiopulmonary impacts and benefits of mitigation and adaptation
oaire.awardTitleEarly life exposure to atmospheric air pollutants and potential DNA damage: Consequences on development and childhood outcomes APPEAL
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/820655/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F115112%2F2016/PT
oaire.citation.endPage46pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage35pt_PT
oaire.citation.titleCirculationpt_PT
oaire.citation.volume147pt_PT
oaire.fundingStreamH2020
person.familyNamedas Neves Pereira da Silva
person.givenNameSusana
person.identifier.ciencia-idB718-8EF6-EBD8
person.identifier.orcid0000-0003-2524-0548
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com página web do editor da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication49b180bc-3e03-4347-9e32-5725fd7142f8
relation.isAuthorOfPublication.latestForDiscovery49b180bc-3e03-4347-9e32-5725fd7142f8
relation.isProjectOfPublication59609b8b-2750-43e0-8fe9-155a4915a572
relation.isProjectOfPublication0c38fa63-8890-47d4-b3d3-1aa47f53b966
relation.isProjectOfPublication.latestForDiscovery59609b8b-2750-43e0-8fe9-155a4915a572

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
CIRCULATIONAHA.122.061832.pdf
Size:
1.02 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

DEP - Artigos em revistas internacionais
DSA - Artigos em revistas internacionais