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On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular models

2020-05-04Journal article Restricted access
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dc.contributor.authorVentura, Célia
dc.contributor.authorPinto, Fátima
dc.contributor.authorLourenço, Ana Filipa
dc.contributor.authorFerreira, Paulo J.T.
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorSilva, Maria João
dc.date.accessioned2021-03-08T15:13:38Z
dc.date.available2021-03-08T15:13:38Z
dc.date.issued2020-05-04
dc.descriptionReviewpt_PT
dc.description.abstractThe need for reaching environmental sustainability encourages research on new cellulosebased materials for a broad range of applications across many sectors of industry. Cellulosic nanomaterials obtained from different sources and with different functionalization are being developed with the purpose of its use in many applications, in pure and composite forms, from consumer products to pharmaceutics and healthcare products. Based on previous knowledge about the possible adverse health effects of other nanomaterials with high aspect ratio and biopersistency in body fluids, e.g., carbon nanotubes, it is expected that the nanometric size of nanocellulose will increase its toxicity as compared to that of bulk cellulose. Several toxicological studies have been performed, in vitro or in vivo, with the aim of predicting the health effects caused by exposure to nanocellulose. Ultimately, their goal is to reduce the risk to humans associated with unintentional environmental or occupational exposure, and the design of safe nanocellulose materials to be used, e.g., as carriers for drug delivery or other biomedical applications, as in wound dressing materials. This review intends to identify the toxicological effects that are elicited by nanocelluloses produced through a topdown approach from vegetal biomass, namely, cellulose nanocrystals and nanofibrils, and relate them with the physicochemical characteristics of nanocellulose. For this purpose, the article provides: (i) a brief review of the types and applications of cellulose nanomaterials; (ii) a comprehensive review of the literature reporting their biological impact, alongside to their specific physicochemical characteristics, in order to draw conclusions about their effects on human health.pt_PT
dc.description.sponsorshipThe authors acknowledge CYTED network NANOCELIA (Transferencia Tecnolo´gica sobre aplicaciones de nanocelulosa en iberoame´rica). The work was funded by FCT/MCTES, Project ToxApp4NanoCELFI (PTDC/ SAU-PUB/32587/2017) through national funds (PIDDAC), and co-funded by ToxOmics – Center for Toxicogenomics and Human Health (UID/BIM/00009/2013). Sara Teixeira is acknowledged for the binucleated cells photo.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citation Cellulose. 2020 May 4;27:5509-44.doi: 10.1007/s10570-020-03176-9pt_PT
dc.identifier.doi10.1007/s10570-020-03176-9pt_PT
dc.identifier.issn0969-0239
dc.identifier.urihttp://hdl.handle.net/10400.18/7361
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relationA predictive toxicology approach to characterize potential respiratory effects of functionalized nanocellulose fibres in a co-culture system
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s10570-020-03176-9pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCellulose Nanofibrilspt_PT
dc.subjectCellulose Nanocrystalspt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectNanotoxicologypt_PT
dc.subjectImmunotoxicitypt_PT
dc.subjectNanocellulose Productionpt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleOn the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular modelspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleA predictive toxicology approach to characterize potential respiratory effects of functionalized nanocellulose fibres in a co-culture system
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-PUB%2F32587%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F00009%2F2013/PT
oaire.citation.endPage5544pt_PT
oaire.citation.startPage5509pt_PT
oaire.citation.titleCellulosept_PT
oaire.citation.volume27pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876
person.familyNameVentura
person.familyNameLouro
person.familyNameSilva
person.givenNameCélia
person.givenNameHenriqueta
person.givenNameMaria Joao
person.identifier2056460
person.identifier157627
person.identifier.ciencia-id6116-89BA-C617
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0002-0637-2222
person.identifier.orcid0000-0001-9744-7332
person.identifier.orcid0000-0002-6060-0716
person.identifier.scopus-author-id6507971479
person.identifier.scopus-author-id55944437600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
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