Publication
Effect of Atmospheric Conditions on Pathogenic Phenotypes of Arcobacter butzleri
| dc.contributor.author | Martins, Rodrigo | |
| dc.contributor.author | Mateus, Cristiana | |
| dc.contributor.author | Domingues, Fernanda | |
| dc.contributor.author | Bücker, Roland | |
| dc.contributor.author | Oleastro, Mónica | |
| dc.contributor.author | Ferreira, Susana | |
| dc.date.accessioned | 2023-03-17T15:03:52Z | |
| dc.date.available | 2023-03-17T15:03:52Z | |
| dc.date.issued | 2022-12-06 | |
| dc.description | This article belongs to the Special Issue Foodborne Pathogens: Infections and Pathogenesis. | pt_PT |
| dc.description.abstract | Arcobacter butzleri is an emergent gram-negative enteropathogenic bacterium widespread in different environments and hosts. During the colonization of the gastrointestinal tract, bacteria face a variety of environmental conditions to successfully establish infection in a new host. One of these challenges is the fluctuation of oxygen concentrations encountered not only throughout the host gastrointestinal tract and defences but also in the food industry. Oxygen fluctuations can lead to modulations in the virulence of the bacterium and possibly increase its pathogenic potential. In this sense, eight human isolates of A. butzleri were studied to evaluate the effects of microaerobic and aerobic atmospheric conditions in stressful host conditions, such as oxidative stress, acid survival, and human serum survival. In addition, the effects on the modulation of virulence traits, such as haemolytic activity, bacterial motility, biofilm formation ability, and adhesion and invasion of the Caco-2 cell line, were also investigated. Overall, aerobic conditions negatively affected the susceptibility to oxygen reactive species and biofilm formation ability but improved the isolates’ haemolytic ability and motility while other traits showed an isolate-dependent response. In summary, this work demonstrates for the first time that oxygen levels can modulate the potential pathogenicity of A. butzleri, although the response to stressful conditions was very heterogeneous among different strains. | pt_PT |
| dc.description.sponsorship | This work was developed within the scope of the CICS-UBI projects UIDB/00709/2020 and UIDP/00709/2020, funded by national funds through the Portuguese Foundation for Science and Technology/MCTES. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Microorganisms. 2022 Dec 6;10(12):2409. doi: 10.3390/microorganisms10122409 | pt_PT |
| dc.identifier.doi | 10.3390/microorganisms10122409 | pt_PT |
| dc.identifier.issn | 2076-2607 | |
| dc.identifier.uri | http://hdl.handle.net/10400.18/8557 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | MDPI | pt_PT |
| dc.relation | Health Sciences Research Centre | |
| dc.relation | Health Sciences Research Centre | |
| dc.relation.publisherversion | https://www.mdpi.com/2076-2607/10/12/2409 | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Aliarcobacter butzleri | pt_PT |
| dc.subject | Virulence | pt_PT |
| dc.subject | Stress Response | pt_PT |
| dc.subject | Atmospheric Conditions | pt_PT |
| dc.subject | Gastrointestinal Infections | pt_PT |
| dc.subject | Infecções Gastrointestinais | pt_PT |
| dc.title | Effect of Atmospheric Conditions on Pathogenic Phenotypes of Arcobacter butzleri | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | Health Sciences Research Centre | |
| oaire.awardTitle | Health Sciences Research Centre | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00709%2F2020/PT | |
| oaire.citation.issue | 12 | pt_PT |
| oaire.citation.startPage | 2409 | pt_PT |
| oaire.citation.title | Microorganisms | pt_PT |
| oaire.citation.volume | 10 | pt_PT |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.embargofct | Acesso de acordo com política editorial da revista. | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isProjectOfPublication | ced21566-cfde-4640-afff-0536a07c1f8f | |
| relation.isProjectOfPublication | e0fbaa7c-391a-479d-9bcf-efb7997d4004 | |
| relation.isProjectOfPublication.latestForDiscovery | ced21566-cfde-4640-afff-0536a07c1f8f |