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Clonal expansion across the seas as seen through CPLP-TB database: a joint effort in cataloguing Mycobacterium tuberculosis genetic diversity in Portuguese-speaking countries

2018-03-17Journal article Restricted access
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dc.contributor.authorPerdigão, João
dc.contributor.authorSilva, Carla
dc.contributor.authorDiniz, Jaciara
dc.contributor.authorPereira, Catarina
dc.contributor.authorMachado, Diana
dc.contributor.authorRamos, Jorge
dc.contributor.authorSilva, Hugo
dc.contributor.authorAbilleira, Fernanda
dc.contributor.authorBrum, Clarice
dc.contributor.authorReis, Ana J.
dc.contributor.authorMacedo, Maíra
dc.contributor.authorScaini, João L.
dc.contributor.authorSilva, Ana B.
dc.contributor.authorEsteves, Leonardo
dc.contributor.authorMacedo, Rita
dc.contributor.authorMaltez, Fernando
dc.contributor.authorClemente, Sofia
dc.contributor.authorCoelho, Elizabeth
dc.contributor.authorViegas, Sofia
dc.contributor.authorRabna, Paulo
dc.contributor.authorRodrigues, Amabélia
dc.contributor.authorTaveira, Nuno
dc.contributor.authorJordao, Luísa
dc.contributor.authorKritski, Afrânio
dc.contributor.authorSilva, José Lapa e
dc.contributor.authorMokrousov, Igor
dc.contributor.authorCouvin, David
dc.contributor.authorRastogi, Nalin
dc.contributor.authorCouto, Isabel
dc.contributor.authorPain, Arnab
dc.contributor.authorMcNerney, Ruth
dc.contributor.authorClark, Taane G.
dc.contributor.authorvon Groll, Andrea
dc.contributor.authorDalla-Costa, Elis R.
dc.contributor.authorRossetti, Maria Lúcia
dc.contributor.authorSilva, Pedro E.A. da
dc.contributor.authorViveiros, Miguel
dc.contributor.authorPortugal, Isabel
dc.date.accessioned2018-03-20T18:14:14Z
dc.date.available2020-01-01T01:30:16Z
dc.date.issued2018-03-17
dc.descriptionLuísa Jordão - Departamento de Saúde Ambiental, Instituto Nacional de Saúde Dr. Ricardo Jorge (INSA); Rita Macedo - Departamento de Doenças Infecciosas, INSA, Lisboa, Portugal.
dc.description.abstractTuberculosis (TB) remains a major health problem within the Community of Portuguese Language Speaking Countries (CPLP). Despite the marked variation in TB incidence across its member-states and continued human migratory flux between countries, a considerable gap in the knowledge on the Mycobacterium tuberculosis population structure and strain circulation between the countries still exists. To address this, we have assembled and analyzed the largest CPLP M.tuberculosis molecular and drug susceptibility dataset, comprised by a total of 1447 clinical isolates, including 423 multidrug-resistant isolates, from five CPLP countries. The data herein presented reinforces Latin American and Mediterranean (LAM) strains as the hallmark of M. tuberculosis populational structure in the CPLP coupled with country-specific differential prevalence of minor clades. Moreover, using high-resolution typing by 24-loci MIRU-VNTR, six cross-border genetic clusters were detected, thus supporting recent clonal expansion across the Lusophone space. To make this data available to the scientific community and public health authorities we developed CPLP-TB (available at http://cplp-tb.ff.ulisboa.pt), an online database coupled with web-based tools for exploratory data analysis. As a public health tool, it is expected to contribute to improved knowledge on the M. tuberculosis population structure and strain circulation within the CPLP, thus supporting the risk assessment of strain-specific trends.pt_PT
dc.description.sponsorshipFinancial support was provided by the European Society of Clinical Microbiology and Infectious Diseases, for which we would like to would like to acknowledge the Study Group for Mycobacterial Infections; Fundação CAPES [PVE-CAPES. 88881.064961/2014-01- Jose R. Lapa e Silva/UFRJ coordinator]; Genotyping and susceptibility profile of Mycobacterium tuberculosis clinical isolates from Rio Grande, Brazil were funded by Apoio a Projetos de Pesquisa em Doenças Negligenciadas, Brazil/MCTI/CNPq/MS-SCTIE – Decit [404081/2012-6] and by Programa Pesquisa para o SUS – PPSUS - FAPERGS/MS/CNPq/SESRS [1193-2551/13-6]; MIRU-VNTR typing and spoligotyping of Mycobacterium tuberculosis clinical isolates from Porto Alegre, Brazil were funded by National Council of Research [CNPq/MCTI/Universal - Project number: 441499/2014-7]; Fundação para a Ciência e a Tecnologia (FCT) Portugal [PTDC/SAU-EPI/122400/2010], part of the EDCTP2 program supported by the European Union; Fundação Calouste Gulbenkian, Portugal [Project ref. P-99934]. JP was supported by a post doc fellowship from project [PTDC/SAU-EPI/122400/2010] and by fellowship [SFRH/BPD/95406/2013] from FCT. The phylogenetic analysis work at Nalin Rastogi's lab was supported by a FEDER grant financed by the European Union and Guadeloupe Region (Programme Opérationnel FEDER-Guadeloupe-Conseil Régional 2014-2020, Grant number 2015-FED-192). IM was supported by Russian Science Foundation (grant 14-14-00292). AP was supported by a faculty baseline funding from KAUST [BAS/1/1020-01-01]. DM was supported by FCT fellowship [SFRH/BPD/100688/2014] and DM, IC MV are thankful to [GHTM UID/Multi/04413/20139] from FCT and to projects “ForDILAB-TB” and “A implementação de um novo método de identificação rápida do complexo M. tuberculosis nos Laboratórios de Referência da Tuberculose de Maputo e Beira” from Fundação Calouste Gulbenkian and the Community of the Portuguese Speaking Countries (CPLP). CS was supported by FCT [SFRH/BD/73579/2010]. TC is funded by the Medical Research Council UK (Grant no. MR/K000551/1 and MR/M01360X/1, MR/N010469/1, MC_PC_15103).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInfect Genet Evol. 2018 Mar 17. pii: S1567-1348(18)30102-3. doi: 10.1016/j.meegid.2018.03.011. [Epub ahead of print]pt_PT
dc.identifier.doi10.1016/j.meegid.2018.03.011pt_PT
dc.identifier.issn1567-1348
dc.identifier.issn1567-7257
dc.identifier.urihttp://hdl.handle.net/10400.18/5410
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationMolecular epidemiology, drug resistance and pathogenesis of HIV and TB in Angola: the Angolan PErinatal HIV Cohort (APEHC)
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1567134818301023pt_PT
dc.subjectTuberculosispt_PT
dc.subjectMIRU-VNTRpt_PT
dc.subjectSpoligotypingpt_PT
dc.subjectDrug Resistancept_PT
dc.subjectMigrationpt_PT
dc.subjectMycobacteriapt_PT
dc.subjectLAMpt_PT
dc.subjectInfecções Respiratóriaspt_PT
dc.titleClonal expansion across the seas as seen through CPLP-TB database: a joint effort in cataloguing Mycobacterium tuberculosis genetic diversity in Portuguese-speaking countriespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMolecular epidemiology, drug resistance and pathogenesis of HIV and TB in Angola: the Angolan PErinatal HIV Cohort (APEHC)
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-EPI%2F122400%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F95406%2F2013/PT
oaire.citation.titleInfection, Genetics and Evolutionpt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamSFRH
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationfc02ba0c-6669-4d88-a799-f980ba859f51
relation.isProjectOfPublication5d3b337f-37ad-40cd-88a9-baa8fa88fa37
relation.isProjectOfPublication.latestForDiscoveryfc02ba0c-6669-4d88-a799-f980ba859f51

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