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Seroprevalence of meningococcal serogroup C bactericidal antibodies in the Portuguese population, a decade after vaccine introduction in the National Immunisation Programme

2021-04-15Journal article Open access
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dc.contributor.authorGonçalves, Paulo
dc.contributor.authorSáez-López, Emma
dc.contributor.authorCarneiro, Sofia
dc.contributor.authorSimões, Maria João
dc.date.accessioned2022-01-28T16:45:59Z
dc.date.available2022-01-28T16:45:59Z
dc.date.issued2021-04-15
dc.description.abstractBackground: The incidence of invasive meningococcal disease due to serogroup C (MenC) decreased in Portugal since the introduction of the conjugate vaccine (MCC) in the free market in 2001 and in the National Immunisation Plan in 2006. Considering the potential waning of the antibody response reported in the literature, the different vaccination schemes that were used in our country over the past decade, and that Neisseria meningitidis serogroup C continues to circulate, the Portuguese population may currently be at increased risk of infection. In the absence of national data, we evaluated the seroprotection level of the Portuguese population against MenC, in order to identify the protected fraction of the population and ponder on the necessity of a booster dose of the MCC vaccine. Methods: We measured serum bactericidal antibody levels against MenC in a representative sample of the population (n = 1500) aged 2-64 years who participated in the 2015/2016 National Serological Survey. Results: A total of 31.1% (466/1500, 95%CI: 29-33%) of the individuals studied were protected against MenC. The geometric mean titre was 6.5. The proportion of seroprotected was particularly low in children aged 2-4 years (<16%) who received a single dose of the vaccine at 12 months of age (vaccination strategy since 2012). The proportion of seroprotected was higher (44.7% to 53.5%) in adolescent and young adults (15-24 years of age), resulting from vaccination during the catch-up campaign at 5-15 years of age. The highest protection rates were observed when the vaccine was administered during adolescence. Conclusion: The small fraction of population seroprotected, combined with the already known waning effect of the antibody response over time, may indicate that the Portuguese population will become progressively more exposed to the risk of infection. Taking in consideration our results, we recommend to change the current vaccination strategy and introduce a booster dose of the MCC vaccine during adolescence.pt_PT
dc.description.sponsorshipNational Institute of Health Doutor Ricardo Jorge, Lisboa, Portugal, and GlaxoSmithKline.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPLoS One. 2021 Apr 15;16(4):e0250103. doi: 10.1371/journal.pone.0250103pt_PT
dc.identifier.doi10.1371/journal.pone.0250103pt_PT
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10400.18/7889
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPublic Library of Sciencept_PT
dc.relation.publisherversionhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0250103pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectNeisseria meningitidispt_PT
dc.subjectImmunisationpt_PT
dc.subjectPortugalpt_PT
dc.subjectNational Immunisation Programmept_PT
dc.subjectVacina conjugada para serogrupo Cpt_PT
dc.subjectImunidadept_PT
dc.subjectPlano de vacinaçãopt_PT
dc.titleSeroprevalence of meningococcal serogroup C bactericidal antibodies in the Portuguese population, a decade after vaccine introduction in the National Immunisation Programmept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue4pt_PT
oaire.citation.startPagee0250103pt_PT
oaire.citation.titlePLoS Onept_PT
oaire.citation.volume16pt_PT
rcaap.embargofctAcesso de acordo com página web do editor da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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