Repository logo
 
Publication

HFE gene polymorphisms and severity in Portuguese patients with multiple sclerosis

2010-06-24Journal article Restricted access
Simple item page
dc.contributor.authorBettencourt, A
dc.contributor.authorSilva, AM
dc.contributor.authorSantos, E
dc.contributor.authorGomes, S
dc.contributor.authorMendonça, D
dc.contributor.authorCosta, PP
dc.contributor.authorFaustino, Paula
dc.contributor.authorSilva, BM
dc.date.accessioned2011-09-06T16:51:02Z
dc.date.available2011-09-06T16:51:02Z
dc.date.issued2010-06-24
dc.descriptionVersão impressa: Eur J Neurol. 2011 Apr;18(4):663-6por
dc.description.abstractBackground: High iron concentrations have been reported in oligodendrocytes, myelin and macrophages in multiple sclerosis (MS) lesions. It has been proposed that HFE gene polymorphisms could have a role in MS. Methods: The C282Y and H63D HFE variants frequencies were determined in 373 patients with MS and compared with a normal population. Results: No significant association was found between HFE polymorphisms and disease susceptibility. An analysis of the association of genotypes with disease severity was performed, and the C282Y allele was more frequent in the aggressive group. Conclusions: Patients carrying the C282Y variant seem to have a worse prognosis.por
dc.identifier.citationEur J Neurol. Epub 2010 Jun 24por
dc.identifier.otherESSN: 1468-1331
dc.identifier.otherdoi: 10.1111/j.1468-1331.2010.03109.x
dc.identifier.urihttp://hdl.handle.net/10400.18/122
dc.language.isoengpor
dc.peerreviewedyespor
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1111/j.1468-1331.2010.03109.x/abstractpor
dc.subjectHFEpor
dc.subjectmultiple sclerosispor
dc.subjectPortugalpor
dc.subjectseveritypor
dc.subjectsusceptibilitypor
dc.subjectDoenças Genéticaspor
dc.titleHFE gene polymorphisms and severity in Portuguese patients with multiple sclerosispor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleEuropean Journal of Neurologypor
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
HFE gene polymorphisms and severity.pdf
Size:
76.7 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

DGH - Artigos em revistas internacionais