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Lymphogranuloma venereum (LGV) ompA-subvariants of the Portuguese collection of Chlamydia trachomatis, 2007–2023

2025-02-06Journal article Restricted access
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dc.contributor.authorLodhia, Zohra
dc.contributor.authorCordeiro, Dora
dc.contributor.authorCorreia, Cristina
dc.contributor.authorJoão, Inês
dc.contributor.authorCarreira, Teresa
dc.contributor.authorNunes, Alexandra
dc.contributor.authorFerreira, Rita
dc.contributor.authorSchäfer, Sandra
dc.contributor.authorAliyeva, Elzara
dc.contributor.authorPortugal, Clara
dc.contributor.authorMonge, Isabel
dc.contributor.authorGonçalves, Elsa
dc.contributor.authorMatos, Susana
dc.contributor.authorDias, Ana Paula
dc.contributor.authorCorte-Real, Rita
dc.contributor.authorVieira, Luís
dc.contributor.authorGomes, Joao Paulo
dc.contributor.authorBorges, Vítor
dc.contributor.authorJose Borrego, Maria
dc.date.accessioned2025-11-14T10:28:48Z
dc.date.available2025-11-14T10:28:48Z
dc.date.issued2025-02-06
dc.description.abstractBackground: Lymphogranuloma venereum (LGV) is a sexually transmitted infection caused by Chlamydia trachomatis ompA-genotypes L1–L3, with increasing numbers of detected cases across Europe. Here, we analysed diversity and temporal distribution of the LGV ompA-subvariants detected in Portugal between 2007 and 2023, in order to better understand the dissemination and diversification landscape of LGV strains. Methods: The collection of the Portuguese National Reference Laboratory includes 1188 LGV ompA-genotyped samples between 2007 and 2023. In-depth analysis of the diversity of LGV ompA-subvariants circulating in Portugal across the years was performed, identifying newly described subvariants and integrating this data in a comprehensive compilation with all representative LGV ompA-subvariants described globally. Results: L2 ompA-variant (L2/434/Bu) was consistently the most frequently detected in our collection, with annual proportions ranging from 34.0% to 82.9%, between 2016 and 2023. L2bV5 was the second most frequent followed by L2b, ranging from 5.0% to 27.9% and 2.6% to 23.7% across the years, respectively, from 2017 to 2023. We highlighted the emergence and considerable increase in circulation of L1-like ompA-subvariants in recent years, representing 13.7% of LGV sequences in 2023. We also identified 13 novel LGV ompA-subvariants that had not been described before, differing by up to three mutations from the respective genotype reference sequences. Conclusions: This study contributes to the worldwide picture of the LGV molecular epidemiology, highlighting the importance of long-term molecular surveillance to monitor the circulation and geographical spread of LGV and to timely identify and track new strains, such as the recently emerging L1-like ompA-subvariants.eng
dc.identifier.citationSex Transm Infect. 2025 Aug 28;101(6):374-379. doi: 10.1136/sextrans-2024-056427
dc.identifier.doi10.1136/sextrans-2024-056427
dc.identifier.eissn1368-4973
dc.identifier.issn1368-4973
dc.identifier.pmid39915233
dc.identifier.urihttp://hdl.handle.net/10400.18/10611
dc.language.isoeng
dc.peerreviewedyes
dc.publisherBMJ Publishing Group
dc.relation.hasversionhttps://sti.bmj.com/content/101/6/374.long
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectChlamydia trachomatis
dc.subjectLymphogranuloma venereum
dc.subjectMolecular Typing
dc.subjectGenetic Variation
dc.subjectGenotype
dc.subjectGenetics
dc.subjectEpidemiology
dc.subjectMicrobiology
dc.subjectInfecções Sexualmente Transmissíveis
dc.subjectPortugal
dc.titleLymphogranuloma venereum (LGV) ompA-subvariants of the Portuguese collection of Chlamydia trachomatis, 2007–2023eng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage379
oaire.citation.issue6
oaire.citation.startPage374
oaire.citation.titleSexually Transmitted Infections
oaire.citation.volume101
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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