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Using human biomonitoring for the risk assessment of polycyclic aromatic hydrocarbons in occupational exposures

2019-09-08Conference object Restricted access
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dc.contributor.authorViegas, Susana
dc.contributor.authorGomes, Bruno Costa
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorSilva, Maria João
dc.contributor.authorJoksić, Agnes Šömen
dc.contributor.authorKirinčič, Stanislava
dc.contributor.authorMahiout, Selma
dc.contributor.authorSantonen, Tiina
dc.date.accessioned2020-05-23T11:01:05Z
dc.date.available2020-05-23T11:01:05Z
dc.date.issued2019-09-08
dc.descriptionAbstracts publicado em: Toxicology Letters. 2019;314S1:S76.
dc.description.abstractBackground and Purpose: The Human Biomonitoring Initiative (HBM4EU) is a joint effort of 28 countries, the European Environment Agency and the European Commission, co-funded under Horizon 2020. HBM4EU is generating evidence of the current exposure of European citizens to chemicals and the possible health effects in order to assess the associated risks and support policy making towards human health protection. Polycyclic aromatic hydrocarbons (PAH) were considered one of the 1st priority substance groups to be addressed. In the scope of this project, the present work aimed to evaluate the added value of human biomonitoring (HBM) for the PAH risk assessment process, in the case of occupational exposure. Methods: An extensive literature search was performed to identify scientific papers published between 2008 and 2018 that included air monitoring and HBM data in several occupational settings based in Europe. Among them, those papers presenting urinary 1-hydroxypyrene (1-OHP) quantification - the most common exposure biomarker of pyrene and a surrogate for exposure to PAHs mixtures - were selected. Based on the 1-OHP values the excess lifetime cancer risk (ELCR) for workers, concerning lung cancer, was estimated following the ECHA recent approach (https://echa.europa.eu/fi/applying-for-authorisation/evaluating-applications). ELCR values calculated using air and HBM data were compared. Results: Based on the criteria described, only 7 out of 28 papers were considered for ELCR estimation. Overall, high ELCR values were estimated (several values higher than 10-4). Moreover, for some studies (3 out of 7) the ELCR estimation using HBM data yielded values higher than those estimated from air monitoring data. This might indicate that, for those specific workplaces, transdermal absorption or even hand-mouth exposure can have an important role in the total exposure to PAH and that the HBM data allows a more accurate PAH exposure assessment. Nevertheless, these findings should be interpreted with caution, since ELCR estimates from air monitoring data are based on Benzo[a]pyrene (BaP) concentrations while HBM-based ELCR determination uses urinary 1-OHP concentration that reflects exposure not only to BaP but to all PAHs, irrespectively of sources or routes of exposure. This work claims attention for two main aspects, namely: i) the exposure levels are still high in some occupational settings and ii) there is a need for developing new occupational studies, applying a set of exposure biomarkers or a more specific biomarker for BaP exposure, which would allow a better ELCR estimation for exposed workers.pt_PT
dc.description.sponsorshipThe HBM4EU project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 733032.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/6767
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectHuman Biomonitoringpt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectPolycyclic Aromatic Hydrocarbons (PAH)pt_PT
dc.subjectRisk Assessmentpt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleUsing human biomonitoring for the risk assessment of polycyclic aromatic hydrocarbons in occupational exposurespt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.conferencePlaceHelsinki, Finlandpt_PT
oaire.citation.title55th Congress of the European Societies of Toxicology (EUROTOX 2019), 8-11 September 2019pt_PT
oaire.fundingStreamH2020
person.familyNameGomes
person.familyNameLouro
person.familyNameSilva
person.givenNameBruno
person.givenNameHenriqueta
person.givenNameMaria Joao
person.identifier157627
person.identifier.ciencia-id1110-883F-9181
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0002-5632-1095
person.identifier.orcid0000-0001-9744-7332
person.identifier.orcid0000-0002-6060-0716
person.identifier.scopus-author-id6507971479
person.identifier.scopus-author-id55944437600
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication9bc1bf0d-2e4a-4bfa-91d4-69cb3fad6eeb
relation.isAuthorOfPublication2361a951-8b9a-4b90-92d6-f6384003a242
relation.isAuthorOfPublicationa7763685-7c34-468d-b958-9dd0aca66db4
relation.isAuthorOfPublication.latestForDiscovery2361a951-8b9a-4b90-92d6-f6384003a242
relation.isProjectOfPublication6815dc2d-ef7e-4535-8dd3-5193c8bffba5
relation.isProjectOfPublication.latestForDiscovery6815dc2d-ef7e-4535-8dd3-5193c8bffba5

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