Publication
Molecular characterization of human T cell leukemia virus type 1 subtypes in a group of infected individuals diagnosed in Portugal and Spain
| dc.contributor.author | Pádua, E. | |
| dc.contributor.author | Rodés, B. | |
| dc.contributor.author | Pérez-Piñar, T. | |
| dc.contributor.author | Silva, A.F. | |
| dc.contributor.author | Jiménez, V. | |
| dc.contributor.author | Ferreira, F. | |
| dc.contributor.author | Toro, C. | |
| dc.date.accessioned | 2016-10-06T14:20:20Z | |
| dc.date.available | 2016-10-06T14:20:20Z | |
| dc.date.issued | 2011-03 | |
| dc.description.abstract | Over the past decade, Portugal and Spain received large numbers of immigrants from HTLV-1 endemic areas. Our aim was to investigate the diversity of subtypes circulating in these two countries and the introduction of new variants. We performed a molecular analysis of HTLV-1 strains in patients diagnosed since 1998. LTR and env proviral sequences from 26 individuals were analyzed to generate phylogenetic trees along with reference HTLV-1 subtypes from several geographic origins. Epidemiological and clinical data were recorded. Most subjects were immigrants (57.7%) from South America and Africa. All isolates belonged to the cosmopolitan A subtype. Most carried the transcontinental subgroup A, but five subjects carried subgroup D and one carried subgroup C, previously unreported in Europe. HTLV strains showed separate clusters linked to the patients' geographic origin. Although subjects with HTLV-1 infection tend not to be engaged in high-risk practices, silent dissemination of a broad diversity of HTLV-1 viruses may still occur. | pt_PT |
| dc.identifier.citation | AIDS Res Hum Retroviruses. 2011 Mar;27(3):317-22. doi: 10.1089/aid.2010.0195. Epub 2010 Oct 18 | pt_PT |
| dc.identifier.doi | 10.1089/aid.2010.0195 | pt_PT |
| dc.identifier.issn | 0889-2229 | |
| dc.identifier.uri | http://hdl.handle.net/10400.18/4036 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Mary Ann Liebert7International Retrovirology Association | pt_PT |
| dc.relation.publisherversion | http://online.liebertpub.com/doi/abs/10.1089/aid.2010.0195 | pt_PT |
| dc.subject | HTLV-1 | pt_PT |
| dc.subject | Subtyping | pt_PT |
| dc.subject | Portugal | pt_PT |
| dc.subject | Spain | pt_PT |
| dc.subject | Infecções Sexualmente Transmissíveis | pt_PT |
| dc.title | Molecular characterization of human T cell leukemia virus type 1 subtypes in a group of infected individuals diagnosed in Portugal and Spain | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 322 | pt_PT |
| oaire.citation.startPage | 317 | pt_PT |
| oaire.citation.title | AIDS Research and Human Retroviruses | pt_PT |
| oaire.citation.volume | 27(3) | pt_PT |
| rcaap.rights | embargoedAccess | pt_PT |
| rcaap.type | article | pt_PT |