Repository logo
 
Publication

Overweight, Obesity, And Cardiovascular Disease In Heterozygous Familial Hypercholesterolaemia: The EAS FH Studies Collaboration Registry

2025-03-24Journal article Open access
Simple item page
dc.contributor.authorElshorbagy, Amany
dc.contributor.authorVallejo-Vaz, Antonio J.
dc.contributor.authorBarkas, Fotios
dc.contributor.authorLyons, Alexander R.M.
dc.contributor.authorStevens, Christophe A.T.
dc.contributor.authorDharmayat, Kanika I.
dc.contributor.authorCatapano, Alberico L.
dc.contributor.authorFreiberger, Tomas
dc.contributor.authorHovingh, G. Kees
dc.contributor.authorMata, Pedro
dc.contributor.authorRaal, Frederick J.
dc.contributor.authorSantos, Raul D.
dc.contributor.authorSoran, Handrean
dc.contributor.authorWatts, Gerald F.
dc.contributor.authorAbifadel, Marianne
dc.contributor.authorAguilar-Salinas, Carlos A.
dc.contributor.authorAlhabib, Khalid F.
dc.contributor.authorAlkhnifsawi, Mutaz
dc.contributor.authorAlmahmeed, Wael
dc.contributor.authorAlnouri, Fahad
dc.contributor.authorAlonso, Rodrigo
dc.contributor.authorAl-Rasadi, Khalid
dc.contributor.authorAl-Sarraf, Ahmad
dc.contributor.authorArca, Marcello
dc.contributor.authorAshavaid, Tester F.
dc.contributor.authorAverna, Maurizio
dc.contributor.authorBanach, Maciej
dc.contributor.authorBecker, Marianne
dc.contributor.authorBinder, Christoph J.
dc.contributor.authorBourbon, Mafalda
dc.contributor.authorBrunham, Liam R.
dc.contributor.authorChlebus, Krzysztof
dc.contributor.authorCorral, Pablo
dc.contributor.authorCruz, Diogo
dc.contributor.authorDavletov, Kairat
dc.contributor.authorDescamps, Olivier S.
dc.contributor.authorDwiputra, Bambang
dc.contributor.authorEzhov, Marat
dc.contributor.authorGroselj, Urh
dc.contributor.authorHarada-Shiba, Mariko
dc.contributor.authorHolven, Kirsten B.
dc.contributor.authorHumphries, Steve E.
dc.contributor.authorKayikcioglu, Meral
dc.contributor.authorKhovidhunkit, Weerapan
dc.contributor.authorLalic, Katarina
dc.contributor.authorLatkovskis, Gustavs
dc.contributor.authorLaufs, Ulrich
dc.contributor.authorLiberopoulos, Evangelos
dc.contributor.authorLima-Martinez, Marcos M.
dc.contributor.authorMaher, Vincent
dc.contributor.authorMarais, A David
dc.contributor.authorMärz, Winfried
dc.contributor.authorMirrakhimov, Erkin
dc.contributor.authorMiserez, André R.
dc.contributor.authorMitchenko, Olena
dc.contributor.authorNawawi, Hapizah
dc.contributor.authorNordestgaard, Børge G.
dc.contributor.authorPanayiotou, Andrie G.
dc.contributor.authorParagh, György
dc.contributor.authorPetrulioniene, Zaneta
dc.contributor.authorPojskic, Belma
dc.contributor.authorPostadzhiyan, Arman
dc.contributor.authorReda, Ashraf
dc.contributor.authorReiner, Željko
dc.contributor.authorReyes, Ximena
dc.contributor.authorSadiq, Fouzia
dc.contributor.authorSadoh, Wilson Ehidiamen
dc.contributor.authorSchunkert, Heribert
dc.contributor.authorShek, Aleksandr B.
dc.contributor.authorStroes, Erik
dc.contributor.authorSu, Ta-Chen
dc.contributor.authorSubramaniam, Tavintharan
dc.contributor.authorSusekov, Andrey V.
dc.contributor.authorTilney, Myra
dc.contributor.authorTomlinson, Brian
dc.contributor.authorTruong, Thanh Huong
dc.contributor.authorTselepis, Alexandros D.
dc.contributor.authorTybjærg-Hansen, Anne
dc.contributor.authorVázquez-Cárdenas, Alejandra
dc.contributor.authorViigimaa, Margus
dc.contributor.authorVohnout, Branislav
dc.contributor.authorYamashita, Shizuya
dc.contributor.authorRay, Kausik K.
dc.contributor.authorEAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)
dc.date.accessioned2025-07-01T10:10:29Z
dc.date.available2025-07-01T10:10:29Z
dc.date.issued2025-03-24
dc.description.abstractBackground and aims: Overweight and obesity are modifiable risk factors for atherosclerotic cardiovascular disease (ASCVD) in the general population, but their prevalence in individuals with heterozygous familial hypercholesterolaemia (HeFH) and whether they confer additional risk of ASCVD independent of LDL cholesterol (LDL-C) remains unclear. Methods: Cross-sectional analysis was conducted in 35 540 patients with HeFH across 50 countries, in the EAS FH Studies Collaboration registry. Prevalence of World Health Organization-defined body mass index categories was investigated in adults (n = 29 265) and children/adolescents (n = 6275); and their association with prevalent ASCVD. Results: Globally, 52% of adults and 27% of children with HeFH were overweight or obese, with the highest prevalence noted in Northern Africa/Western Asia. A higher overweight/obesity prevalence was found in non-high-income vs. high-income countries. Median age at familial hypercholesterolaemia diagnosis in adults with obesity was 9 years older than in normal weight adults. Obesity was associated with a more atherogenic lipid profile independent of lipid-lowering medication. Prevalence of coronary artery disease increased progressively across body mass index categories in both children and adults. Compared with normal weight, obesity was associated with higher odds of coronary artery disease in children (odds ratio 9.28, 95% confidence interval 1.77-48.77, adjusted for age, sex, lipids, and lipid-lowering medication) and coronary artery disease and stroke in adults (odds ratio 2.35, 95% confidence interval 2.10-2.63 and odds ratio 1.65, 95% confidence interval 1.27-2.14, respectively), but less consistently with peripheral artery disease. Adjusting for diabetes, hypertension and smoking modestly attenuated the associations. Conclusions: Overweight and obesity are common in patients with HeFH and contribute to ASCVD risk from childhood, independent of LDL-C and lipid-lowering medication. Sustained body weight management is needed to reduce the risk of ASCVD in HeFH.eng
dc.description.sponsorshipThe EAS FHSC is an academic initiative that has received funding from a Pfizer Independent Grant for Learning & Change 2014 (16157823) and from investigator-initiated research grants to Imperial College London from Amgen, Merck Sharp & Dohme, Sanofi–Aventis, Daiichi Sankyo, and Regeneron. K.I.D. acknowledges support for a PhD Studentship from the National Institute for Health and Care Research (NIHR) Applied Research Collaboration Northwest London. K.K.R. acknowledges support from the NIHR Applied Research Collaboration Northwest London and Imperial NIHR Biomedical Research Centre. A.J.V.-V. acknowledges support from the Programme “Beatriz Galindo” from the Ministry of Universities, Spain, and University of Seville, Spain. A.L.C. is supported in part by the grant Ricerca Corrente from the Ministry of Health to IRCCS MultiMedica. H.N. acknowledges support from the Ministry of Higher Education (MOHE), National Professorial Council (MPN) and Universiti knologi MARA (UiTM), Malaysia. The Austrian Familiar Hypercholesterolemia Registry, which contributed to the FHSC registry, has been supported by funds form the Austrian Heart Foundation and the Tyrolean Regional Government.
dc.identifier.citationEur Heart J . 2025 Mar 24;46(12):1127-1140. doi: 10.1093/eurheartj/ehae791
dc.identifier.doi10.1093/eurheartj/ehae791
dc.identifier.issn0195-668X
dc.identifier.pmid39801189
dc.identifier.urihttp://hdl.handle.net/10400.18/10516
dc.language.isoeng
dc.peerreviewedyes
dc.publisherOxford University Press
dc.relation.hasversionhttps://academic.oup.com/eurheartj/article/46/12/1127/7933169
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAdiposity
dc.subjectAtherosclerosis
dc.subjectDyslipidaemia
dc.subjectInsulin Resistance
dc.subjectDoenças Cardio e Cérebro-vasculares
dc.titleOverweight, Obesity, And Cardiovascular Disease In Heterozygous Familial Hypercholesterolaemia: The EAS FH Studies Collaboration Registryeng
dc.typejournal article
dcterms.referenceshttps://academic.oup.com/eurheartj/article/46/12/1127/7933169#supplementary-data
dspace.entity.typePublication
oaire.citation.endPage1140
oaire.citation.issue12
oaire.citation.startPage1127
oaire.citation.titleEuropean Heart Journal
oaire.citation.volume46
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
MafaldaBourbon_2025. Overweight, obesity, and cardiovascular disease in heterozygous familial hypercholesterolaemia the EAS FH Studies Collaboration registry..pdf
Size:
1.11 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
4.03 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

DPSPDNT - Artigos em revistas internacionais
INSA - Artigos em revistas internacionais