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Assessment of the mechanisms and pathways of fish contamination and mercury-selenium antagonism

2020-09-16Conference object Restricted access
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dc.contributor.authorRibeiro, M.
dc.contributor.authorZephyr, N.
dc.contributor.authorLeufroy, A.
dc.contributor.authorCoelho, I.
dc.contributor.authorDanion, M.
dc.contributor.authorCastanheira, I.
dc.contributor.authorGuerin, T.
dc.contributor.authorJitaru, P.
dc.date.accessioned2021-03-10T08:59:31Z
dc.date.available2021-03-10T08:59:31Z
dc.date.issued2020-09-16
dc.description.abstractAIM Mercury (Hg) is one of the most dangerous chemical contaminants for humans and the environment. This is due to its extreme toxicity, particularly in the methylated form, denominated methylmercury (CH3Hg), which is easily absorbed by the body (bioaccumulation). CH3Hg is present in low concentrations in water and in water sediments, and can greatly increase its concentration in aquatic organisms, often reaching more than 85% of total Hg. Therefore, the main source of exposure to CH3Hg is fish consumption, in particular fish from higher trophic levels, since its content tends to increase along the food chain (biomagnification). Nevertheless, it is interesting to note that mercury´s bioavailability seems to be linked to selenium (Se) levels. The Se protective effects against Hg bioaccumulation and toxicity has been identified for the last decades, although the mechanism is still poorly understood. The aim of this study is to accurately assess the Hg-Se interaction in fish and the human dietary exposure. MATERIAL AND METHODS A bioassay was carried out in a representative freshwater fish (rainbow trout) in collaboration with the fish viral pathology unit of ANSES (Ploufragan-Plouzané laboratory). Fish were dietary exposed to CH3Hg under controlled conditions, in the presence or absence of SeMet. The final concentration of CH3Hg and SeMet in the diets was respectively 0,2 μg g-1 and 5 μg g-1. Briefly, six feeding protocols were compared: a non-supplemented diet (control group), a diet supplemented with SeMet, a diet supplemented with MeHg, a diet supplemented with both MeHg and SeMet, a diet supplemented first with MeHg for 1 month and then with SeMet for 2 months and a diet supplemented with SeMet for 1 month and then with MeHg for 2 months. The edible part of fish (muscle) was analysed for SeT and Hgt concentrations by ICP-MS after different time of exposure (1 month, 2 months and 3 months).pt_PT
dc.description.sponsorshipEste trabalho foi desenvolvido com o apoio da FCT - Project MERSEL-FISH.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/7399
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectMercurypt_PT
dc.subjectSeleniumpt_PT
dc.subjectMethylmercurypt_PT
dc.subjectSelenomethioninept_PT
dc.subjectDietary Exposurept_PT
dc.subjectComposição dos Alimentospt_PT
dc.titleAssessment of the mechanisms and pathways of fish contamination and mercury-selenium antagonismpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlacePraga, Republica Checapt_PT
oaire.citation.title5th IMEKOFOODS - Metrology for Sustainable Food Production, 16-18 September 2020pt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typeconferenceObjectpt_PT

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