A molecular approach to frailty in older adults

Costa, S.; Costa, C.; Silva, S.; Carvalho, J.; Laffon, B.; Teixeira, João Paulo

http://hdl.handle.net/10400.18/3653

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Abstract(s)

Population ageing is transforming economies and societies across the world. The European Commission has appointed Ageing (and Healthy Ageing) one of the main priorities in the next Horizon 2020 Framework Program as part of the Societal Challenges in Europe. The prevention of Frailty in old age is one of the key actions identified. Frailty is a multidimensional syndrome characterized by increased vulnerability and functional decline that may be reversed, but if not addressed leads to long-term disability and hospitalisation. The aim of the present study is (a) to identify new cellular and molecular biomarkers associated with “frailty” that might be detected before clinical manifestations become evident, (b) to clarify the effect of physical exercise to prevent or even reverse frailty, and (c) to evaluate the potential influence of physical exercise on the biomarkers studied.