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The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer

2017-03Journal article Restricted access
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dc.contributor.authorVale, Nuno
dc.contributor.authorGouveia, Maria J.
dc.contributor.authorRinaldi, Gabriel
dc.contributor.authorSantos, Júlio
dc.contributor.authorSantos, Lúcio Lara
dc.contributor.authorBrindley, Paul J.
dc.contributor.authorda Costa, José M. Correia
dc.date.accessioned2018-03-22T19:52:00Z
dc.date.available2018-03-22T19:52:00Z
dc.date.issued2017-03
dc.description.abstractUrogenital schistosomiasis is a neglected tropical disease that can lead to bladder cancer. How urogenital schistosomiasis induces carcinogenesis remains unclear, although there is evidence that the human blood fluke Schistosoma haematobium, the infectious agent of urogenital schistosomiasis, releases estradiol-like metabolites. These kind of compounds have been implicated in other cancers. Aiming for enhanced understanding of the pathogenesis of the urogenital schistosomiasis-induced bladder cancer, here we review, interpret, and discuss findings of estradiol-like metabolites detected in both the parasite and in the human urine during urogenital schistosomiasis. Moreover, we predict pathways and enzymes that are involved in the production of these metabolites emphasizing their potential effects on the dysregulation of the tumor suppressor gene p53 expression during urogenital schistosomiasis. Enhanced understanding of these potential carcinogens may not only shed light on urogenital schistosomiasis-induced neoplasia of the bladder, but would also facilitate development of interventions and biomarkers for this and other infection-associated cancers at large.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTumour Biol. 2017 Mar;39(3):1010428317692247. doi: 10.1177/1010428317692247.pt_PT
dc.identifier.doi10.1177/1010428317692247pt_PT
dc.identifier.issn1010-4283
dc.identifier.urihttp://hdl.handle.net/10400.18/5466
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSAGE Publicationspt_PT
dc.relation.publisherversionhttp://journals.sagepub.com/doi/abs/10.1177/1010428317692247?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmedpt_PT
dc.subjectAnimalspt_PT
dc.subjectCell Transformation, Neoplasticpt_PT
dc.subjectDNA Adductspt_PT
dc.subjectEstradiolpt_PT
dc.subjectHumanspt_PT
dc.subjectReactive Oxygen Speciespt_PT
dc.subjectSchistosoma haematobiumpt_PT
dc.subjectSchistosomiasis haematobiapt_PT
dc.subjectTumor Suppressor Protein p53pt_PT
dc.subjectUrinary Bladderpt_PT
dc.subjectUrinary Bladder Neoplasmspt_PT
dc.subjectVias de Transdução de Sinal e Patologias Associadaspt_PT
dc.subjectInfecções Sistémicas e Zoonosespt_PT
dc.titleThe role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancerpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue3pt_PT
oaire.citation.startPage1010428317692247pt_PT
oaire.citation.titleTumor Biologypt_PT
oaire.citation.volume39pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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