Repository logo
 
Publication

Occupational exposure to metals and PAHs: combining literature-based exposure and in vitro hazard data towards a mixture risk assessment a mixture risk assessment

2021-10Conference object Restricted access
Simple item page
dc.contributor.authorTavares, Ana Maria
dc.contributor.authorAlves, Inês
dc.contributor.authorMoreira, Rodrigo
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorLadeira, Carina
dc.contributor.authorViegas, Susana
dc.contributor.authorLoureiro, Susana
dc.contributor.authorSantonen, Tiina
dc.contributor.authorGöen, Thomas
dc.contributor.authorKortenkamp, Andrew
dc.contributor.authorLuijten, Mirjam
dc.contributor.authorSilva, Maria João
dc.date.accessioned2022-01-14T14:48:31Z
dc.date.available2022-01-14T14:48:31Z
dc.date.issued2021-10
dc.descriptionAbstract publicado em: Toxicol Lett. 2021 Sep;350(Suppl.):S210 (P21-14). https://doi.org/10.1016/S0378-4274(21)00729-3pt_PT
dc.description.abstractThe environment within industrial settings is commonly characterized by the existence of a complex mixture of chemicals from different raw materials and transformation processes. Occupational co-exposure to chromium (Cr), Nickel (Ni), and Polycyclic Aromatic Hydrocarbons (PAHs) may occur in diverse workplaces, such as the aeronautic and waste management, (e.g incineration) sectors. Such co-exposure rais-es concern in terms of occupational health, as these substances are recognized lung carcinogens and mainly act by genotoxic mechanisms, increasing the likelihood of interactive toxic effects. The fact that cur-rent regulatory practices are usually focused on single chemical sub-stances, without integrating the possibility of combined or aggregated exposures and effects, may lead to a risk underestimation.In this work, developed under the scope of HBM4EU Initiative (https://www.hbm4eu.eu), a literature-based mixture risk assess-ment (MRA) exercise for occupational exposure to metals and PAHs was performed. In addition, in vitro toxicity data was obtained for the same mixtures to provide support to its hazard assessment.Human biomonitoring (HBM) data on Cr(VI), Ni and/or PAHs was extracted from occupational studies conducted in the European Un-ion and searched in literature databases. Selected reference values were used to calculate risk quotients (RQ) for each substance based on the retrieved exposure data; the combined risk was given by the sum of the RQ, i.e., the Background Exposure Exceedance Score(BEES).In parallel, we evaluated the combined cyto- and genotoxicity of the same chemicals (assessed by the MTT and micronucleus assays) in the human alveolar A549 cell line.In most of the analysed studies, we observed that BEES levels, estimated from the exposure to metals mixture or to metals and PAHs, exceeded RQ levels considered acceptable for the individual substances. Only two studies, conducted in hazard waste incinerator settings, presented urinary exposure levels for the three substances. They showed a value of BEES of concern (>1) for all exposure sce-narios, even for workers performing activities considered of low ex-posure or no-exposure, such as laboratory and administrative work-ers. In vitro assays supported that A549 cells exposure to these substances resulted in interactive cytotoxic and genotoxic effects that may underlie health effects different from those predicted from single exposures.Our findings show the limitations of applying occupational expo-sure reference values defined on a single substance basis to work-places where exposure to chemical mixtures occur, highlighting the relevance of performing MRA as a more realistic approach to guide suitable risk management measures in occupational settingspt_PT
dc.description.sponsorshipFunded by the HBM4EU Initiative (GA 733032), ChemMix (IDI&CA, IPL, 2019) projects and by FCT/MCTES through national funds (UIDB/00009/ 2020; UIDP/00009/2020).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/7850
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationUIDB/00009/ 2020pt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.relationCentre for Toxicogenomics and Human Health
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectMixture Toxicitypt_PT
dc.subjectHuman Biomonitoringpt_PT
dc.subjectOccupational Exposurept_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleOccupational exposure to metals and PAHs: combining literature-based exposure and in vitro hazard data towards a mixture risk assessment a mixture risk assessmentpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardTitleCentre for Toxicogenomics and Human Health
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00009%2F2020/PT
oaire.citation.conferencePlace(online)pt_PT
oaire.citation.title56th Congress of the European Societies of Toxicology (EUROTOX 2021): Toxicology of the next generation, 27 Sep - 1 Oct 2021pt_PT
oaire.fundingStreamH2020
oaire.fundingStream6817 - DCRRNI ID
person.familyNameLouro
person.familyNameSilva
person.givenNameHenriqueta
person.givenNameMaria Joao
person.identifier157627
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0001-9744-7332
person.identifier.orcid0000-0002-6060-0716
person.identifier.scopus-author-id6507971479
person.identifier.scopus-author-id55944437600
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication2361a951-8b9a-4b90-92d6-f6384003a242
relation.isAuthorOfPublicationa7763685-7c34-468d-b958-9dd0aca66db4
relation.isAuthorOfPublication.latestForDiscoverya7763685-7c34-468d-b958-9dd0aca66db4
relation.isProjectOfPublication6815dc2d-ef7e-4535-8dd3-5193c8bffba5
relation.isProjectOfPublication8836ec79-2300-487a-97ad-75e98cfabcfa
relation.isProjectOfPublication.latestForDiscovery6815dc2d-ef7e-4535-8dd3-5193c8bffba5

Files

Original bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
21_14_SILVA_ePoster final.pdf
Size:
854.52 KB
Format:
Adobe Portable Document Format
Download
No Thumbnail Available
Name:
Tavares et al_Abst Toxicol Letters 2021.pdf
Size:
545.23 KB
Format:
Adobe Portable Document Format
Download

Collections

DGH - Posters/abstracts em congressos internacionais