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SRC/RAC1 Pathway and other NIS Plasma Membrane Interactors in NIS Regulation

2023-09Conference object Restricted access
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dc.contributor.authorSilva, Ana Luísa
dc.contributor.authorMatos, Paulo
dc.date.accessioned2024-01-05T11:49:21Z
dc.date.available2024-01-05T11:49:21Z
dc.date.issued2023-09
dc.description.abstractThe Sodium/Iodide Symporter (NIS) is responsible for the uptake of iodide into thyroid follicular cells, which is required for thyroid hormone production. NIS is present in most differentiated thyroid carcinoma (DTC) cells, allowing radioactive iodine (RAI) to be used to eliminate any residual disease after thyroidectomy. However, in advanced DTC, a significant proportion of metastatic lesions stop taking up iodide and become refractory to RAI therapy. This impairment of iodide uptake is mainly caused by defective functional expression of NIS, due to dysregulated transcriptional and posttranscriptional events. In this presentation, part of a Symposium entitled “Thyroid Cancer Basic: New Molecules for Better Treatments”, I will talk about how we discovered that signaling by the small GTPase RAC1 plays a crucial role in regulating NIS expression, both at the transcriptional and posttranscriptional levels, and how this might impact RAI therapy in advanced DTC.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/8861
dc.language.isoengpt_PT
dc.peerreviewednopt_PT
dc.publisherInstituto Nacional de Saúde Doutor Ricardo Jorge, IPpt_PT
dc.subjectVias de Transdução de Sinal e Patologias Associadaspt_PT
dc.subjectThyroid Cancerpt_PT
dc.subjectSodium Iodide Symporterpt_PT
dc.subjectRAC1pt_PT
dc.titleSRC/RAC1 Pathway and other NIS Plasma Membrane Interactors in NIS Regulationpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceMilan, Itáliapt_PT
oaire.citation.title45th European Thyroid Association Annual Meeting, 9-12 september 2023pt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT

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