Publicação
Signaling Pathways of Proteostasis Network Unraveled by Proteomic Approaches on the Understanding of Misfolded Protein Rescue
| dc.contributor.author | Gomes-Alves, Patricia | |
| dc.contributor.author | Neves, Sofia | |
| dc.contributor.author | Penque, Deborah | |
| dc.date.accessioned | 2013-02-12T12:15:23Z | |
| dc.date.available | 2013-02-12T12:15:23Z | |
| dc.date.issued | 2011 | |
| dc.description.abstract | Attempts to promote normal processing and function of F508del-CFTR, the most common mutant in cystic fibrosis (CF), have been described as potential therapeutic strategies in the management of this disease. Here we described the proteomic approaches, namely two-dimensional electrophoresis (2DE), mass spectrometry (MS), and bioinformatics tools used in our recent studies to gain insight into the proteins potentially involved in lowtemperature or mutagenic treatment-induced rescue process of F508del-CFTR. The proteins identified are part of the proteostasis network, such as the unfolded protein response (UPR) signaling pathways that may regulate the processing of CF transmembrane conductance regulator (CFTR) through the folding and trafficking progression. The complete characterization of these signaling pathways and their regulators in CF will certainly contribute to the development of novel therapeutic strategies against CF. | por |
| dc.identifier.citation | Methods Enzymol. 2011;491:217-33(Chapter thirteen) | por |
| dc.identifier.issn | 0076-6879 | |
| dc.identifier.other | doi: 10.1016/B978-0-12-385928-0.00013-4 | |
| dc.identifier.uri | http://hdl.handle.net/10400.18/1282 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Elsevier | por |
| dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/B9780123859280000134 | por |
| dc.subject | Cystic Fibrosis | por |
| dc.subject | Proteomics | por |
| dc.subject | Mass Spectrometry | por |
| dc.subject | Genómica Funcional e Estrutural | por |
| dc.subject | Proteostasis Network | por |
| dc.subject | UPR | por |
| dc.subject | ER stress | por |
| dc.subject | ERAD | por |
| dc.subject | F508del-CFTR | por |
| dc.title | Signaling Pathways of Proteostasis Network Unraveled by Proteomic Approaches on the Understanding of Misfolded Protein Rescue | por |
| dc.type | book part | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 233 | por |
| oaire.citation.startPage | 217 | por |
| oaire.citation.title | Methods in Enzymology. Volume 491 - The Unfolded Protein Response and Cellular Stress, Part C | por |
| oaire.citation.volume | 491 | por |
| rcaap.rights | restrictedAccess | por |
| rcaap.type | bookPart | por |
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