Publicação
Interleukine-6 promoter polymorphism -174g/C association with chronic nephropathy of the graft: a meta-analysis
| dc.contributor.author | Lima, Bruno | |
| dc.contributor.author | Mendes, Miguel | |
| dc.contributor.author | Alves, Helena | |
| dc.date.accessioned | 2015-06-25T16:41:13Z | |
| dc.date.available | 2015-06-25T16:41:13Z | |
| dc.date.issued | 2015-04 | |
| dc.description.abstract | Despite being the subject of several independent studies, the relationship between Interleukine-6 (IL-6) polymorphisms and kidney graft outcome continue to be plagued by contradictory conclusions. In this meta-analysis we collect all the relevant studies to further clarify the association of IL-6 genotypes and Chronic Nephropathy of the Graft (CNG). Relevant published data was retrieved through Medline with references to kidney transplant outcome and IL-6 polymorphisms. Odds ratios (OR) with 95% confidence intervals (CI) were used to assess the strength of the association. Z test was used to determine the significance of the pooled OR. Statistical heterogeneity was measured using the Q statistic. A total of 6 studies, including 474 transplanted patients with CNG and 731 transplanted patients as control group with stable graft function, were collected. The distribution of IL-6 polymorphims was evaluated and no heterogeneity was observed among individual estimates. Original data was combined using the fixed-effects model. For the total population, we found that G/G and G/C IL-6 genotypes were less common in the CNG group than in the control group with an OR of 0.61, (95 % CI=0.42–0.87), and p=0.006, which shows a protective association of IL-6 high producers genotypes in the CNG group. IL-6 is both a major proinflammatory cytokine and an important anti-inflammatory mediator, these complex actions would yield variable effects on atherosclerosis and cardiovascular risk profile in kidney transplant recipients. Our comprehensive meta-analysis indicated that there is sufficient evidence to demonstrate an association between the IL-6 polymorphisms and CNG after kidney transplantation. | por |
| dc.identifier.citation | Tissue Antigens. 2015; 85(5):407(P214) | por |
| dc.identifier.doi | 10.1111/tan.12557 | |
| dc.identifier.uri | http://hdl.handle.net/10400.18/3063 | |
| dc.language.iso | eng | por |
| dc.publisher | John Wiley & Sons Ltd | por |
| dc.relation.publisherversion | http://onlinelibrary.wiley.com/doi/10.1111/tan.12557/abstract | por |
| dc.subject | Interleukine-6 | por |
| dc.subject | Chronic Nephropathy | por |
| dc.title | Interleukine-6 promoter polymorphism -174g/C association with chronic nephropathy of the graft: a meta-analysis | por |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Genebra, Suíça | por |
| oaire.citation.endPage | 407 | por |
| oaire.citation.startPage | 407 | por |
| oaire.citation.title | 29th European Immunogenetics and Histocompatibility Conference, 26-29 April 2015 | por |
| oaire.citation.volume | 85(5) | por |
| rcaap.rights | openAccess | por |
| rcaap.type | conferenceObject | por |