Publicação
The Implication of mRNA degradation disorders on human dISease: focus on DIS3 and DIS3-Like enzymes
| dc.contributor.author | Saramago, Margarida | |
| dc.contributor.author | da Costa, Paulo J. | |
| dc.contributor.author | Viegas, Sandra C. | |
| dc.contributor.author | Arraiano, Cecília M. | |
| dc.date.accessioned | 2020-04-30T21:28:05Z | |
| dc.date.available | 2020-04-30T21:28:05Z | |
| dc.date.issued | 2019-08-07 | |
| dc.description | Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1157). | pt_PT |
| dc.description | L. Romão (ed.), The mRNA Metabolism in Human Disease, Advances in Experimental Medicine and Biology 1157, https://doi.org/10.1007/978-3-030-19966-1_4 | pt_PT |
| dc.description.abstract | RNA degradation is considered a critical posttranscriptional regulatory checkpoint, maintaining the correct functioning of organisms. When a specific RNA transcript is no longer required in the cell, it is signaled for degradation through a number of highly regulated steps. Ribonucleases (or simply RNases) are key enzymes involved in the control of RNA stability. These enzymes can perform the RNA degradation alone or cooperate with other proteins in RNA degradation complexes. Important findings over the last years have shed light into eukaryotic RNA degradation by members of the RNase II/RNB family of enzymes. DIS3 enzyme belongs to this family and represents one of the catalytic subunits of the multiprotein complex exosome. This RNase has a diverse range of functions, mainly within nuclear RNA metabolism. Humans encode two other DIS3-like enzymes: DIS3L (DIS3L1) and DIS3L2. DIS3L1 also acts in association with the exosome but is strictly cytoplasmic. In contrast, DIS3L2 acts independently of the exosome and shows a distinctive preference for uridylated RNAs. These enzymes have been shown to be involved in important cellular processes, such as mitotic control, and associated with human disorders like cancer. This review shows how the impairment of function of each of these enzymes is implicated in human disease. | pt_PT |
| dc.description.sponsorship | This work was supported by project LISBOA-01-0145-FEDER-007660 (Microbiologia Molecular, Estrutural e Celular) funded by FEDER funds through COMPETE2020 – Programa Operacional Competitividade e Internacionalização (POCI) and by national funds from FCT (Fundação para a Ciência e a Tecnologia); project PTDC/BIA-MIC/1399/2014 to CMA and project PTDC/BIM-MEC/3749/2014 to SCV. In addition, FCT provides postdoctoral grant ref. SFRH/ BPD/109464/2015 to MS. SCV was financed by program IF of FCT (ref IF/00217/2015). | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Adv Exp Med Biol. 2019;1157:85-98. doi: 10.1007/978-3-030-19966-1_4 | pt_PT |
| dc.identifier.doi | 10.1007/978-3-030-19966-1_4 | pt_PT |
| dc.identifier.issn | 0065-2598 | |
| dc.identifier.uri | http://hdl.handle.net/10400.18/6564 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Springer Verlag | pt_PT |
| dc.relation.publisherversion | https://link.springer.com/chapter/10.1007%2F978-3-030-19966-1_4 | pt_PT |
| dc.subject | Cancer | pt_PT |
| dc.subject | DIS3 | pt_PT |
| dc.subject | DIS3L1 | pt_PT |
| dc.subject | DIS3L2 | pt_PT |
| dc.subject | Exoribonuclease | pt_PT |
| dc.subject | Exosome | pt_PT |
| dc.subject | Polyadenylation | pt_PT |
| dc.subject | RNA Degradation | pt_PT |
| dc.subject | RNase | pt_PT |
| dc.subject | Uridylation | pt_PT |
| dc.subject | Doenças Genéticas | pt_PT |
| dc.subject | Genómica Funcional e Estrutural | pt_PT |
| dc.title | The Implication of mRNA degradation disorders on human dISease: focus on DIS3 and DIS3-Like enzymes | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 98 | pt_PT |
| oaire.citation.startPage | 85 | pt_PT |
| oaire.citation.title | Advances in Experimental Medicine and Biology | pt_PT |
| oaire.citation.volume | 1157 | pt_PT |
| rcaap.embargofct | De acordo com política editorial da revista. | pt_PT |
| rcaap.rights | embargoedAccess | pt_PT |
| rcaap.type | article | pt_PT |