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CCR5-Delta32: Implications in SLE development

2013-10-29Journal article Restricted access
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dc.contributor.authorCarvalho, C.
dc.contributor.authorCalvisi, S.L.
dc.contributor.authorLeal, B.
dc.contributor.authorBettencourt, A.
dc.contributor.authorMarinho, A.
dc.contributor.authorAlmeida, I.
dc.contributor.authorFarinha, F.
dc.contributor.authorPinho-Costa, P.
dc.contributor.authorSilva, B.M.
dc.contributor.authorVasconcelos, C.
dc.date.accessioned2014-03-31T15:45:23Z
dc.date.available2014-03-31T15:45:23Z
dc.date.issued2013-10-29
dc.description.abstractSystemic lupus erythematosus (SLE) is a prototypical autoimmune disease with strong genetic and environmental components. Previous studies have shown increased levels of several chemokines in active SLE. C-C chemokine receptor type 5 (CCR5) is involved in the recruitment of inflammatory cells into tissues, and mechanisms modulating CCR5 expression and function may interfere in SLE development, influencing the clinical course of the disease. The aim of this study was to evaluate the possible association between the CCR5{increment}32 base-pair deletion polymorphism and SLE disease in a group of Portuguese patients. A total of 219 patients with SLE and 205 healthy individuals were studied. The frequency of CCR5[del]32 heterozygotes was lower in patients with SLE than in controls (8% vs. 15% OR = 0.5162; P = 0.0319), suggesting a protective association between CCR5[del]32 allele and SLE. These results highlight the protective role of Th1 cells that express CCR5 in SLE pathogenesis.por
dc.identifier.citationInt J Immunogenet. 2014 Jun;41(3):236-41. doi: 10.1111/iji.12094. Epub 2013 Oct 29por
dc.identifier.issn1744-3121
dc.identifier.otherdoi: 10.1111/iji.12094
dc.identifier.urihttp://hdl.handle.net/10400.18/2202
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherJohn Wiley & Sons Ltdpor
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1111/iji.12094/pdfpor
dc.subjectSystemic Lupus Erythematosuspor
dc.subjectCCR5por
dc.subjectAutoimmune Diseasespor
dc.subjectGenetic Associationpor
dc.subjectComplex Disease Geneticspor
dc.titleCCR5-Delta32: Implications in SLE developmentpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleInternational Journal of Immunogeneticspor
rcaap.rightsembargoedAccesspor
rcaap.typearticlepor

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