Repository logo
 
Publication

Evidence for an association of prenatal exposure to particulate matter with clinical severity of Autism Spectrum Disorder

2023-04-05Journal article Open access
Simple item page
dc.contributor.authorSantos, João Xavier
dc.contributor.authorSampaio, Pedro
dc.contributor.authorRasga, Célia
dc.contributor.authorMartiniano, Hugo
dc.contributor.authorFaria, Clarissa
dc.contributor.authorCafé, Cátia
dc.contributor.authorOliveira, Alexandra
dc.contributor.authorDuque, Frederico
dc.contributor.authorOliveira, Guiomar
dc.contributor.authorSousa, Lisete
dc.contributor.authorNunes, Ana
dc.contributor.authorMoura Vicente, Astrid
dc.date.accessioned2023-10-11T15:23:43Z
dc.date.available2023-10-11T15:23:43Z
dc.date.issued2023-04-05
dc.description.abstractEarly-life exposure to air pollutants, including ozone (O3), particulate matter (PM2.5 or PM10, depending on diameter of particles), nitrogen dioxide (NO2) and sulfur dioxide (SO2) has been suggested to contribute to the etiology of Autism Spectrum Disorder (ASD). In this study, we used air quality monitoring data to examine whether mothers of children with ASD were exposed to high levels of air pollutants during critical periods of pregnancy, and if higher exposure levels may lead to a higher clinical severity in their offspring. We used public data from the Portuguese Environment Agency to estimate exposure to these pollutants during the first, second and third trimesters of pregnancy, full pregnancy and first year of life of the child, for 217 subjects with ASD born between 2003 and 2016. These subjects were stratified in two subgroups according to clinical severity, as defined by the Autism Diagnostic Observational Schedule (ADOS). For all time periods, the average levels of PM2.5, PM10 and NO2 to which the subjects were exposed were within the admissible levels defined by the European Union. However, a fraction of these subjects showed exposure to levels of PM2.5 and PM10 above the admissible threshold. A higher clinical severity was associated with higher exposure to PM2.5 (p = 0.001), NO2 (p = 0.011) and PM10 (p = 0.041) during the first trimester of pregnancy, when compared with milder clinical severity. After logistic regression, associations with higher clinical severity were identified for PM2.5 exposure during the first trimester (p = 0.002; OR = 1.14, 95%CI: 1.05–1.23) and full pregnancy (p = 0.04; OR = 1.07, 95%CI: 1.00–1.15) and for PM10 (p = 0.02; OR = 1.07, 95%CI: 1.01–1.14) exposure during the third trimester. Exposure to PM is known to elicit neuropathological mechanisms associated with ASD, including neuroinflammation, mitochondrial disruptions, oxidative stress and epigenetic changes. These results offer new insights on the impact of earlylife exposure to PM in ASD clinical severity.pt_PT
dc.description.sponsorshipThis work was supported by Fundaçao ˜ para a Ciˆencia e a Tecnologia (FCT), through funding to the project “Gene-environment interactions in Autism Spectrum Disorder” (Grant PTDC/MED-OUT/28937/2017) and to Research Center Grants UIDB/04046/2020 and UIDP/04046/2020 (to BioISI) and UIDB/00006/2020 (to Centro de Estatística e Aplicaçoes ˜ da Universidade de Lisboa). Joao ˜ Xavier Santos is a fellow of the BioSys PhD Program and an awardee of a scholarship funded by FCT with reference PD/BD/114,386/2016.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEnviron Res. 2023 Jul 1;228:115795. doi: 10.1016/j.envres.2023.115795. Epub 5 April 2023pt_PT
dc.identifier.doi10.1016/j.envres.2023.115795pt_PT
dc.identifier.issn0013-9351
dc.identifier.urihttp://hdl.handle.net/10400.18/8709
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationBiosystems and Integrative Sciences Institute
dc.relationBiosystems and Integrative Sciences Institute
dc.relationCentre of Statistics and its Applications
dc.relationGene- Environment Intereactions in Austim Spectrum Disorders ASD
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S001393512300587X?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectAir Pollutionpt_PT
dc.subjectAutism Spectrum Disorderpt_PT
dc.subjectClinical Severitypt_PT
dc.subjectEarly-life Exposurept_PT
dc.subjectParticulate Matterpt_PT
dc.subjectPregnancypt_PT
dc.subjectPerturbações do Desenvolvimento Infantil e Saúde Mentalpt_PT
dc.subjectAutismopt_PT
dc.subjectPortugalpt_PT
dc.titleEvidence for an association of prenatal exposure to particulate matter with clinical severity of Autism Spectrum Disorderpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleBiosystems and Integrative Sciences Institute
oaire.awardTitleBiosystems and Integrative Sciences Institute
oaire.awardTitleCentre of Statistics and its Applications
oaire.awardTitleGene- Environment Intereactions in Austim Spectrum Disorders ASD
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FMED-OUT%2F28937%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04046%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04046%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/PD%2FBD%2F114386%2F2016/PT
oaire.citation.startPage115795pt_PT
oaire.citation.titleEnvironmental Researchpt_PT
oaire.citation.volume228pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamOE
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acoro com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication7ab739a8-b1fa-4111-a6c2-7c768f057353
relation.isProjectOfPublicationdc433369-36fd-4935-bd52-c56aa49c72e1
relation.isProjectOfPublicatione8390b4d-1833-4925-a0ab-5fff0527efaa
relation.isProjectOfPublication1828b27c-0dae-4001-a56b-8e520a5b181e
relation.isProjectOfPublication0415a4cd-2605-4be4-9278-fa7ae7cbfe07
relation.isProjectOfPublication.latestForDiscovery7ab739a8-b1fa-4111-a6c2-7c768f057353

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
1-s2.0-S001393512300587X-main (1) (1).pdf
Size:
2.14 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

DPSPDNT - Artigos em revistas internacionais