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Emergence of the Asian lineage of Zika virus in Angola: an outbreak investigation

2019-10-19Journal article Restricted access
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dc.contributor.authorHill, S.C.
dc.contributor.authorVasconcelos, J.
dc.contributor.authorNeto, Z.
dc.contributor.authorJandondo, D.
dc.contributor.authorZé-Zé, L.
dc.contributor.authorAguiar, R.S.
dc.contributor.authorXavier, J.
dc.contributor.authorThézé, J.
dc.contributor.authorMirandela, M.
dc.contributor.authorMicolo Cândido, A.L.
dc.contributor.authorVaz, F.
dc.contributor.authorSebastião, C.D.S.
dc.contributor.authorWu, C.H.
dc.contributor.authorKraemer, M.U.G.
dc.contributor.authorMelo, A.
dc.contributor.authorSchamber-Rei, B.L.F.
dc.contributor.authorde Azevedos, G.S.
dc.contributor.authorTanuri, T.
dc.contributor.authorHiga, L.M.
dc.contributor.authorClemente, C.
dc.contributor.authorda Silva, S.P.
dc.contributor.authorda Silva Candido, D.
dc.contributor.authorClaro, I.M.
dc.contributor.authorQuibuco, D.
dc.contributor.authorDomingos, C.
dc.contributor.authorPocongo, B.
dc.contributor.authorWatts, A.G.
dc.contributor.authorKhan, K.
dc.contributor.authorAlcantara, L.C.J.
dc.contributor.authorSabino, E.C.
dc.contributor.authorLackritz, E.
dc.contributor.authorPybus, O.G.
dc.contributor.authorAlves, M.J.
dc.contributor.authorAfonso, J.
dc.contributor.authorFaria, N.R.
dc.date.accessioned2020-04-23T15:36:46Z
dc.date.available2020-05-19T00:30:14Z
dc.date.issued2019-10-19
dc.descriptionFree PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31559967/pt_PT
dc.description.abstractBackground: Zika virus infections and suspected microcephaly cases have been reported in Angola since late 2016, but no data are available about the origins, epidemiology, and diversity of the virus. We aimed to investigate the emergence and circulation of Zika virus in Angola. Methods: Diagnostic samples collected by the Angolan Ministry of Health as part of routine arboviral surveillance were tested by real-time reverse transcription PCR by the Instituto Nacional de Investigação em Saúde (Ministry of Health, Luanda, Angola). To identify further samples positive for Zika virus and appropriate for genomic sequencing, we also tested samples from a 2017 study of people with HIV in Luanda. Portable sequencing was used to generate Angolan Zika virus genome sequences from three people positive for Zika virus infection by real-time reverse transcription PCR, including one neonate with microcephaly. Genetic and mobility data were analysed to investigate the date of introduction and geographical origin of Zika virus in Angola. Brain CT and MRI, and serological assays were done on a child with microcephaly to confirm microcephaly and assess previous Zika virus infection. Findings: Serum samples from 54 people with suspected acute Zika virus infection, 76 infants with suspected microcephaly, 24 mothers of infants with suspected microcephaly, 336 patients with suspected dengue virus or chikungunya virus infection, and 349 samples from the HIV study were tested by real-time reverse transcription PCR. Four cases identified between December, 2016, and June, 2017, tested positive for Zika virus. Analyses of viral genomic and human mobility data suggest that Zika virus was probably introduced to Angola from Brazil between July, 2015, and June, 2016. This introduction probably initiated local circulation of Zika virus in Angola that continued until at least June, 2017. The infant with microcephaly in whom CT and MRI were done had brain abnormalities consistent with congenital Zika syndrome and serological evidence for Zika virus infection. Interpretation: Our analyses show that autochthonous transmission of the Asian lineage of Zika virus has taken place in Africa. Zika virus surveillance and surveillance of associated cases of microcephaly throughout the continent is crucial.pt_PT
dc.description.sponsorshipRoyal Society, Wellcome Trust, Global Challenges Research Fund (UK Research and Innovation), Africa Oxford, John Fell Fund, Oxford Martin School, European Research Council, Departamento de Ciência e Tecnologia/Ministério da Saúde/National Council for Scientific and Technological Development, and Ministério da Educação/Coordenação de Aperfeicoamento de Pessoal de Nível Superior.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLancet Infect Dis. 2019 Oct;19(10):1138-1147. doi: 10.1016/S1473-3099(19)30293-2pt_PT
dc.identifier.doi10.1016/S1473-3099(19)30293-2pt_PT
dc.identifier.issn1473-3099
dc.identifier.urihttp://hdl.handle.net/10400.18/6493
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherlsevier/ Lancetpt_PT
dc.relation.publisherversionhttps://www.thelancet.com/journals/laninf/article/PIIS1473-3099(19)30293-2/fulltextpt_PT
dc.subjectEmergencept_PT
dc.subjectAsianpt_PT
dc.subjectZika Viruspt_PT
dc.subjectAngolapt_PT
dc.subjectInfecções Sistémicas e Zoonosespt_PT
dc.titleEmergence of the Asian lineage of Zika virus in Angola: an outbreak investigationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1147pt_PT
oaire.citation.issue10pt_PT
oaire.citation.startPage1138pt_PT
oaire.citation.titleLancet Infectious Diseasespt_PT
oaire.citation.volume19pt_PT
rcaap.embargofctDe acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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