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Genetic Meningococcal Antigen Typing System (gMATS): A genotyping tool that predicts 4CMenB strain coverage worldwide

2019-02-08Journal article Open access
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dc.contributor.authorMuzzi, Alessandro
dc.contributor.authorBrozzi, Alessandro
dc.contributor.authorSerino, Laura
dc.contributor.authorBodini, Margherita
dc.contributor.authorAbad, Raquel
dc.contributor.authorCaugant, Dominique
dc.contributor.authorComanducci, Maurizio
dc.contributor.authorLemos, Ana Paula
dc.contributor.authorGorla, Maria Cecilia
dc.contributor.authorKřížová, Pavla
dc.contributor.authorMikula, Claudia
dc.contributor.authorMulhall, Robert
dc.contributor.authorNissen, Michael
dc.contributor.authorNohynek, Hanna
dc.contributor.authorSimões, Maria João
dc.contributor.authorSkoczyńska, Anna
dc.contributor.authorStefanelli, Paola
dc.contributor.authorTaha, Muhamed-Kheir
dc.contributor.authorToropainen, Maija
dc.contributor.authorTzanakaki, Georgina
dc.contributor.authorVadivelu-Pechai, Kumaran
dc.contributor.authorWatson, Philip
dc.contributor.authorVazquez, Julio A.
dc.contributor.authorRajam, Gowrisankar
dc.contributor.authorRappuoli, Rino
dc.contributor.authorBorrow, Ray
dc.contributor.authorMedini, Duccio
dc.date.accessioned2020-05-09T15:15:10Z
dc.date.available2020-05-09T15:15:10Z
dc.date.issued2019-02-08
dc.description.abstractBackground: The Meningococcal Antigen Typing System (MATS) was developed to identify meningococcus group B strains with a high likelihood of being covered by the 4CMenB vaccine, but is limited by the requirement for viable isolates from culture-confirmed cases. We examined if antigen genotyping could complement MATS in predicting strain coverage by the 4CMenB vaccine. Methods: From a panel of 3912 MATS-typed invasive meningococcal disease isolates collected in England and Wales in 2007-2008, 2014-2015 and 2015-2016, and in 16 other countries in 2000-2015, 3481 isolates were also characterized by antigen genotyping. Individual associations between antigen genotypes and MATS coverage for each 4CMenB component were used to define a genetic MATS (gMATS). gMATS estimates were compared with England and Wales human complement serum bactericidal assay (hSBA) data and vaccine effectiveness (VE) data from England. Results: Overall, 81% of the strain panel had genetically predictable MATS coverage, with 92% accuracy and highly concordant results across national panels (Lin's accuracy coefficient, 0.98; root-mean-square deviation, 6%). England and Wales strain coverage estimates were 72-73% by genotyping (66-73% by MATS), underestimating hSBA values after four vaccine doses (88%) and VE after two doses (83%). The gMATS predicted strain coverage in other countries was 58-88%. Conclusions: gMATS can replace MATS in predicting 4CMenB strain coverage in four out of five cases, without requiring a cultivable isolate, and is open to further improvement. Both methods underestimated VE in England. Strain coverage predictions in other countries matched or exceeded England and Wales estimates.pt_PT
dc.description.sponsorshipThis work was supported by GlaxoSmithKline Biologicals SA,including all costs associated with the development and publishingof the manuscript.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVaccine. 2019 Feb 8;37(7):991-1000. doi: 10.1016/j.vaccine.2018.12.061. Epub 2019 Jan 17pt_PT
dc.identifier.doi10.1016/j.vaccine.2018.12.061pt_PT
dc.identifier.issn0264-410X
dc.identifier.urihttp://hdl.handle.net/10400.18/6634
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier/ GlaxoSmithKline Biologicals SA.pt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0264410X19300325?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subject4CMenB Vaccinept_PT
dc.subjectGenotypingpt_PT
dc.subjectNeisseria meningitidis Serogroup Bpt_PT
dc.subjectStrain Coveragept_PT
dc.subjectgMATSpt_PT
dc.subjectInfecções Respiratóriaspt_PT
dc.titleGenetic Meningococcal Antigen Typing System (gMATS): A genotyping tool that predicts 4CMenB strain coverage worldwidept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1000pt_PT
oaire.citation.issue7pt_PT
oaire.citation.startPage991pt_PT
oaire.citation.titleVaccinept_PT
oaire.citation.volume37pt_PT
rcaap.embargofctDe acordo com o editor online da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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