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Baseline data and associations between urinary biomarkers of polycyclic aromatic hydrocarbons, blood pressure, hemogram, and lifestyle among wildland firefighters

2024-03-06Journal article Open access
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.fosCiências Naturais::Ciências Biológicas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorBarros, Bela
dc.contributor.authorPaiva, Ana Margarida
dc.contributor.authorOliveira, Marta
dc.contributor.authorAlves, Sara
dc.contributor.authorEsteves, Filipa
dc.contributor.authorFernandes, Adília
dc.contributor.authorVaz, Josiana
dc.contributor.authorSlezakova, Klara
dc.contributor.authorCosta, Solange
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorMorais, Simone
dc.date.accessioned2025-04-04T15:05:52Z
dc.date.available2025-04-04T15:05:52Z
dc.date.issued2024-03-06
dc.description.abstractIntroduction: Available literature has found an association between firefighting and pathologic pathways leading to cardiorespiratory diseases, which have been linked with exposure to polycyclic aromatic hydrocarbons (PAHs). PAHs are highlighted as priority pollutants by the European Human Biomonitoring Initiative in occupational and non-occupational contexts. Methods: This cross-sectional study is the first to simultaneously characterize six creatinine-adjusted PAHs metabolites (OHPAHs) in urine, blood pressure, cardiac frequency, and hemogram parameters among wildland firefighters without occupational exposure to fire emissions (> 7 days), while exploring several variables retrieved via questionnaires. Results: Overall, baseline levels for total OHPAHs levels were 2 to 23-times superior to the general population, whereas individual metabolites remained below the general population median range (except for 1-hydroxynaphthalene+1-hydroxyacenaphtene). Exposure to gaseous pollutants and/or particulate matter during work-shift was associated with a 3.5-fold increase in total OHPAHs levels. Firefighters who smoke presented 3-times higher total concentration of OHPAHs than non-smokers (p < 0.001); non-smoker females presented 2-fold lower total OHPAHs (p = 0.049) than males. 1-hydroxypyrene was below the recommended occupational biological exposure value (2.5 μg/L), and the metabolite of carcinogenic PAH (benzo(a)pyrene) was not detected. Blood pressure was above 120/80 mmHg in 71% of subjects. Firefighters from the permanent intervention team presented significantly increased systolic pressure than those who performed other functions (p = 0.034). Tobacco consumption was significantly associated with higher basophils (p = 0.01–0.02) and hematocrit (p = 0.03). No association between OHPAHs and blood pressure was found. OHPAHs concentrations were positively correlated with monocyte, basophils, large immune cells, atypical lymphocytes, and mean corpuscular volume, which were stronger among smokers. Nevertheless, inverse associations were observed between fluorene and pyrene metabolites with neutrophils and eosinophils, respectively, in non-smokers. Hemogram was negatively affected by overworking and lower physical activity. Conclusion: This study suggests possible associations between urinary PAHs metabolites and health parameters in firefighters, that should be further assessed in larger groups.eng
dc.description.sponsorshipThe authors are grateful to Fundação para a Ciência e a Tecnologia for financial support through national funds by BioFirEx: PCIF/SSO/0017/2018 (http://doi.org/10.54499/PCIF/SSO/0017/2018) and 2022.05381.PTDC (http://doi.org/10.54499/2022.05381.PTDC). BB (PhD grant 2020.07394.BD) and MO (scientific contract CEECIND/03666/2017; https://doi. org/10.54499/CEECIND/03666/2017/CP1427/CT0007) are thankful to Fundação para a Ciência e a Tecnologia, Ministério da Ciência, Tecnologia e Ensino Superior for their financial support. This work also received support by UIDB/50006/2020 (http://doi.org/10.54499/UIDB/50006/2020), UIDP/ 50006/2020 (http://doi.org/10.54499/UIDP/50006/2020), LA/P/0008/2020 (http://doi.org/10.54499/LA/P/0008/2020) by the Fundação para a Ciência e a Tecnologia (FCT-MCTES).
dc.identifier.citationFront Public Health. 2024 Mar 6:12:1338435. doi: 10.3389/fpubh.2024.1338435. eCollection 2024
dc.identifier.doi10.3389/fpubh.2024.1338435
dc.identifier.eissn2296-2565
dc.identifier.pmid38510349
dc.identifier.urihttp://hdl.handle.net/10400.18/10487
dc.language.isoeng
dc.peerreviewedyes
dc.publisherFrontiers Media
dc.relationA panel of (bio)markers for the surveillance of firefighter's health and safety.
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationForest Fire emissions: Exposure data and potential health risks for firefighters and the general population.
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relation.hasversionhttps://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1338435/full
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectFirefighters Health
dc.subjectBiomarkers of Exposure
dc.subjectSmoking
dc.subjectBiomonitoring
dc.subjectHydroxylated Polycyclic Aromatic Hydrocarbons
dc.subjectBiomarkers of Effect
dc.subjectAr e Saúde Ocupacional
dc.titleBaseline data and associations between urinary biomarkers of polycyclic aromatic hydrocarbons, blood pressure, hemogram, and lifestyle among wildland firefighterseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleA panel of (bio)markers for the surveillance of firefighter's health and safety.
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleForest Fire emissions: Exposure data and potential health risks for firefighters and the general population.
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de Projetos de Investigação Científica e Desenvolvimento Tecnológico no Âmbito da Prevenção e Combate a Incêndios Florestais - 2018/PCIF%2FSSO%2F0017%2F2018/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//2020.07394.BD/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0008%2F2020/PT
oaire.citation.startPage133843
oaire.citation.titleFrontiers in Public Health
oaire.citation.volume12
oaire.fundingStreamConcurso de Projetos de Investigação Científica e Desenvolvimento Tecnológico no Âmbito da Prevenção e Combate a Incêndios Florestais - 2018
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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