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Exposure to per-and poly-fluoroalkyl substances and respiratory and skin effects in children and adolescents: A systematic review and meta-analysis

2025-07-05Artigo científico Acesso aberto
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dc.contributor.authorHatem, Georges
dc.contributor.authorFaria, Ana Margarida
dc.contributor.authorPinto, Mariana Bessa
dc.contributor.authorSalamova, Amina
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorCosta, Carla
dc.contributor.authorMadureira, Joana
dc.date.accessioned2026-02-20T16:42:34Z
dc.date.available2026-02-20T16:42:34Z
dc.date.issued2025-07-05
dc.description.abstractDespite being previously banned due to long-term health effects, Per- and polyfluoroalkyl substances (PFAS) remain widespread in the environment, accumulating in animals and humans. This systematic review and meta-analysis explores associations between exposure to PFAS and asthma onset, wheezing, atopic dermatitis, and eczema in children and adolescents while addressing exposure timing and sex-specific differences. After comprehensive search conducted in several databases, including risk of bias, study heterogeneity, and quality of evidence evaluation, the review included 28 observational studies, most with low risk of bias in all domains. PFAS exposure was not significantly associated with asthma onset (OR:1.03, CI:0.99;1.07), but revealed significantly lower association in the prenatal period (OR:0.97, CI:0.94;0.99), higher in the postnatal period (OR:1.20, CI:1.07;1.35), and no differences among sexes. PFAS exposure (mainly prenatal) was associated with 4 % significantly lower odds of wheezing (OR:0.96, CI:0.94;0.98), higher in girls (OR:0.94, CI:0.91;0.98) than in boys (OR:0.97, CI:0.94;1.00). No significant impact was noted on atopic dermatitis (OR:1.04, CI:0.94;1.16), while PFAS exposure was associated with 8 % significantly lower eczema odds (OR:0.92, CI:0.89;0.96). Evidence was insufficient to perform sensitivity analyses on atopic dermatitis and eczema. Additional research is needed on the impact of synergistic and co-exposure to other pollutants on children and adolescents' health.eng
dc.description.abstractHighlights: - Prenatal PFAS exposure showed lower asthma odds as opposed to postnatal exposure. - PFAS exposure decreased wheezing odds by 4 %, with a stronger effect in girls. - PFAS exposure had no significant impact on atopic dermatitis odds. - PFAS exposure significantly decreased eczema odds by 8 %.eng
dc.description.sponsorshipThe authors wish to thank the Foundation for Science and Technology (FCT, Portugal) for financial support to the EDC(Mind)2 project (PTDC/CTA-AMB/3040/2021; DOI https://doi.org/10.54499/PTDC/CTA-AMB/3040/2021), Epidemiology Research Unit – Institute of Public Health, University of Porto (EPI-Unit: UIDB/04750/2020; DOI https://doi.org/10.54499/UIDB/04750/2020), the Laboratory for Integrative and Translational Research in Population Health (ITR: LA/P/0064/2020; DOI https://doi.org/10.54499/LA/P/0064/2020), and the individual fellowships 2022.11261.BD and 2024.02722.BDANA.
dc.identifier.citationJ Hazard Mater. 2025 Jul 5:491:137978. doi: 10.1016/j.jhazmat.2025.137978. Epub 2025 Mar 19
dc.identifier.doi10.1016/j.jhazmat.2025.137978
dc.identifier.issn0304-3894
dc.identifier.pmid40120265
dc.identifier.urihttp://hdl.handle.net/10400.18/10977
dc.language.isoen
dc.peerreviewedyes
dc.publisherElsevier
dc.relationPTDC/CTA-AMB/3040/2021
dc.relationEpidemiology Research Unit - Institute of Public Health, University of Porto
dc.relationLaboratory for Integrative and Translational Research in Population Health
dc.relation2024.02722.BDANA
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S0304389425008945?via%3Dihub
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAsthma Onset
dc.subjectAtopic Dermatitis
dc.subjectEczema
dc.subjectPer- and Polyfluoroalkyl Substances
dc.subjectWheezing
dc.subjectToxicologia
dc.titleExposure to per-and poly-fluoroalkyl substances and respiratory and skin effects in children and adolescents: A systematic review and meta-analysiseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberPTDC/CTA-AMB/3040/2021
oaire.awardNumberUIDB/04750/2020
oaire.awardNumberLA/P/0064/2020
oaire.awardTitleEpidemiology Research Unit - Institute of Public Health, University of Porto
oaire.awardTitleLaboratory for Integrative and Translational Research in Population Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de Projetos IC&DT em Todos os Domínios Científicos/PTDC%2FCTA-AMB%2F3040%2F2021/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04750%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0064%2F2020/PT
oaire.citation.startPage137978
oaire.citation.titleJournal of Hazardous Materials
oaire.citation.volume491
oaire.fundingStreamConcurso de Projetos IC&DT em Todos os Domínios Científicos
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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relation.isProjectOfPublication.latestForDiscoveryd2b25b54-c60e-4030-bb5a-660fbf0426a9

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