Cytotoxicity of Clay-TiO2 nanostructures in human HepG2 cells

Bessa, Maria João; Reinosa, Julian Jimenez; Fernandez, José Francisco; Banares, Miguel; Teixeira, João Paulo; Costa, Carla

http://hdl.handle.net/10400.18/3566

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Authors

Bessa, Maria João

Reinosa, Julian Jimenez

Fernandez, José Francisco

Banares, Miguel

Teixeira, João Paulo

Costa, Carla

Abstract(s)

Background and Objective: In the last decades, nanotechnology has become increasingly attractive to different scientific and industrial fields as it becomes evident that manufactured nanomaterials offer a whole new range of potentialities. On the other hand, different studies have been showing that nanomaterials can be toxic and therefore may harm both the environment and the human health. Recent advances in the production of nanomaterials lead to the development of new structures, namely of nanoparticles immobilized in microstructures that by presenting new physico-chemical features must be test in regards to their toxic potential. Therefore, the aim of the present work was the evaluation of the in vitro cytotoxicity of TiO2 nanoparticles (TiO2 NPs) immobilized in clay (C-TiO2 ) in a hepatocellular carcinoma human cell line (HepG2). In order to understand the origin of the observed effects, TiO2 NPs and clay alone were also studied.