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The Effects of Tetrabromobisphenol A (TBBPA) on the Mussel Mytilus galloprovincialis: A Multi-Biomarker Approach

2024-04-03Artigo científico Acesso aberto
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dc.contributor.authorCopeto, Sandra
dc.contributor.authorGanço, Sara
dc.contributor.authorFerreira, Inês João
dc.contributor.authorSilva, Marco
dc.contributor.authorMotta, Carla
dc.contributor.authorDiniz, Mário
dc.date.accessioned2025-03-24T15:23:58Z
dc.date.available2025-03-24T15:23:58Z
dc.date.issued2024-04-03
dc.description.abstractTetrabromobisphenol A (TBBPA) is a fire-retardant containing bromine, produced in large quantities worldwide and extensively used in several industrial products. This compound was identified as a potential contaminant of the environment, causing toxicity to organisms. However, its toxicity remains poorly understood in marine bivalves. The first objective of this work was to evaluate the impact of TBBPA on mussels (Mytilus galloprovincialis) exposed for 28 days to various concentrations of TBBPA (0, 1, 10, and 100 µg·L−1), by assessing stress biomarkers’ responses (Glutathione S-transferase, superoxide dismutase, catalase, lipid peroxidation, total antioxidant capacity, total ubiquitin, caspase-3 and acetylcholinesterase). The results showed that lower concentrations (1 and 10 µg·L−1) were efficiently detoxified, as suggested by GST activities, which were supported by the responses of the other biomarkers. The most pronounced effects were observed in animals exposed to the highest concentration of TBBPA (100 µg·L−1), suggesting oxidative stress. Additionally, significant strong correlations were found between total antioxidant capacity and some biomarkers (superoxide dismutase and lipid peroxidation), showing that processes involved in oxidative stress fighting are working to avoid cell injury. In brief, mussels’ defense mechanisms were capable of dealing with exposure to the lower concentrations tested. Despite this, the risk of consuming shellfish or other fishery products contaminated with TBBPA should be a cause for concern.pt_PT
dc.description.sponsorshipThis work was funded by national funds from FCT—Fundação para a Ciência e a Tecnologia, I.P., in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences, UCIBIO; the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy, i4HB; and by the Associate Laboratory for Green Chemistry, LAQV, which is financed by national funds from FCT/MCTES (UID/QUI/50006/2019).
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationOceans. 2024 Apr 3;5(2):181-195. doi: 10.3390/oceans5020011
dc.identifier.doi10.3390/oceans5020011pt_PT
dc.identifier.eissn2673-1924
dc.identifier.urihttp://hdl.handle.net/10400.18/10458
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPI
dc.relationApplied Molecular Biosciences Unit
dc.relationApplied Molecular Biosciences Unit
dc.relationInstitute for Health and Bioeconomy
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relation.hasversionhttps://www.mdpi.com/2673-1924/5/2/11
dc.relation.publisherversionhttps://www.mdpi.com/2673-1924/5/2/11pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectTetrabromobisphenol Apt_PT
dc.subjectMytilus galloprovincialispt_PT
dc.subjectBiomarkerspt_PT
dc.subjectOxidative Stresspt_PT
dc.subjectSegurança Alimentar
dc.titleThe Effects of Tetrabromobisphenol A (TBBPA) on the Mussel Mytilus galloprovincialis: A Multi-Biomarker Approachpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleInstitute for Health and Bioeconomy
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0140%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F50006%2F2019/PT
oaire.citation.endPage195pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage181pt_PT
oaire.citation.titleOcean Science
oaire.citation.volume5pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationf10335ba-6a11-4a72-b082-182ce09d548d
relation.isProjectOfPublicationb6e46a61-d241-4879-b841-169d21cd75b9
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relation.isProjectOfPublication5961359e-cce9-41c3-a5e6-b6170c28f652
relation.isProjectOfPublication.latestForDiscoveryb6e46a61-d241-4879-b841-169d21cd75b9

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