Repository logo
 
Publication

Inflammatory Microenvironment Modulation of Alternative Splicing in Cancer: A Way to Adapt

2020-03-05Book part Restricted access
Simple item page
dc.contributor.authorSilva, Ana Luísa
dc.contributor.authorFaria, Márcia
dc.contributor.authorMatos, Paulo
dc.date.accessioned2021-03-18T11:07:42Z
dc.date.available2021-03-18T11:07:42Z
dc.date.issued2020-03-05
dc.descriptionReview
dc.description.abstractThe relationship between inflammation and cancer has been long recognized by the medical and scientific community. In the last decades, it has returned to the forefront of clinical oncology since a wealth of knowledge has been gathered about the cells, cytokines and physiological processes that are central to both inflammation and cancer. It is now robustly established that chronic inflammation can induce certain cancers but also that solid tumors, in turn, can initiate and perpetuate local inflammatory processes that foster tumor growth and dissemination. Inflammation is the hallmark of the innate immune response to tissue damage or infection, but also mediates the activation, expansion and recruitment to the tissues of cells and antibodies of the adaptive immune system. The functional integration of both components of the immune response is crucial to identify and subdue tumor development, progression and dissemination. When this tight control goes awry, altered cells can avoid the immune surveillance and even subvert the innate immunity to promote their full oncogenic transformation. In this chapter, we make a general overview of the most recent data linking the inflammatory process to cancer. We start with the overall inflammatory cues and processes that influence the relationship between tumor and the microenvironment that surrounds it and follow the ever-increasing complexity of processes that end up producing subtle changes in the splicing of certain genes to ascertain survival advantage to cancer cells.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationIn: Serpa J. (eds) Tumor Microenvironment. Adv Exp Med Biol . 2020;1219:243-258. doi: 10.1007/978-3-030-34025-4_13pt_PT
dc.identifier.doi10.1007/978-3-030-34025-4_13pt_PT
dc.identifier.isbn978-3-030-34025-4
dc.identifier.urihttp://hdl.handle.net/10400.18/7531
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relation.publisherversionhttps://link.springer.com/chapter/10.1007%2F978-3-030-34025-4_13pt_PT
dc.subjectCytokinespt_PT
dc.subjectMetastasispt_PT
dc.subjectInflammationpt_PT
dc.subjectCancerpt_PT
dc.subjectAlternative Splicingpt_PT
dc.subjectTumor Microenvironmentpt_PT
dc.subjectVias de Transdução de Sinalpt_PT
dc.subjectVias de Transdução de Sinal e Patologias Associadaspt_PT
dc.titleInflammatory Microenvironment Modulation of Alternative Splicing in Cancer: A Way to Adaptpt_PT
dc.typebook part
dspace.entity.typePublication
oaire.citation.endPage258pt_PT
oaire.citation.startPage243pt_PT
oaire.citation.titleAdvances in Experimental Medicine and Biologypt_PT
oaire.citation.volume1219pt_PT
rcaap.embargofctAcesso de acordo com página web do editor da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typebookPartpt_PT

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Silva AL et al_A Way to Adapt_Adv Exp Med Biol 2020.pdf
Size:
9.96 MB
Format:
Adobe Portable Document Format
Download

Collections

DGH - Capítulos (ou partes) de livros