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The adaptor protein SHC1 is recruited to tyrosine-phosphorylated plasma membrane chloride channels
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Orientador(es)
Resumo(s)
Protein kinase Syk was recently found to phosphorylate a specific tyrosine
residue in three distinct disease-related chloride transport proteins: CFTR (in cystic
fibrosis (CF) or chronic obstructive pulmonary disease (COPD)), NKCC2 and KCC3 (in
kidney function and hypertension).
Descrição
Palavras-chave
Vias de Transdução de Sinal e Patologias Associadas WNK Protein Kinases Fibrose Quística Hipertensão Arterial Fosforilação Tirosina