The adaptor protein SHC1 is recruited to tyrosine-phosphorylated plasma membrane chloride channels

Loureiro, Claudia; Matos, Paulo; Clarke, Luka; Jordan, Peter

http://hdl.handle.net/10400.18/5196

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Abstract(s)

Protein kinase Syk was recently found to phosphorylate a specific tyrosine residue in three distinct disease-related chloride transport proteins: CFTR (in cystic fibrosis (CF) or chronic obstructive pulmonary disease (COPD)), NKCC2 and KCC3 (in kidney function and hypertension).