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Safety and efficacy of a feed additive consisting of 6‐phytase produced by Aspergillus oryzae DSM 33737 (HiPhorius™) for all poultry, all Suidae and all fin fish (DSM Nutritional Products Ltd)

2024-03-11Journal article Open access
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dc.contributor.authorBampidis, Vasileios
dc.contributor.authorAzimonti, Giovanna
dc.contributor.authorBastos, Maria de Lourdes
dc.contributor.authorChristensen, Henrik
dc.contributor.authorDusemund, Birgit
dc.contributor.authorDurjava, Mojca
dc.contributor.authorKouba, Maryline
dc.contributor.authorLópez‐Alonso, Marta
dc.contributor.authorLópez Puente, Secundino
dc.contributor.authorMarcon, Francesca
dc.contributor.authorMayo, Baltasar
dc.contributor.authorPechová, Alena
dc.contributor.authorPetkova, Mariana
dc.contributor.authorRamos, Fernando
dc.contributor.authorVilla, Roberto Edoardo
dc.contributor.authorWoutersen, Ruud
dc.contributor.authorDierick, Noël
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorMartelli, Giovanna
dc.contributor.authorTosti, Luca
dc.contributor.authorAnguita, Montserrat
dc.contributor.authorFirmino, Joana P.
dc.contributor.authorInnocenti, Matteo L.
dc.contributor.authorPetenatti, Elisa
dc.contributor.authorPizzo, Fabiola
dc.contributor.authorOrtuño, Jordi
dc.contributor.authorEFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
dc.date.accessioned2025-03-06T13:26:50Z
dc.date.available2025-03-06T13:26:50Z
dc.date.issued2024-03-11
dc.descriptionEFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Members: Henriqueta Louro, Departamento de Genética Humana, INSA.
dc.description.abstractFollowing a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of 6‐phytase produced by the genetically modified strain Aspergillus oryzae DSM 33737 (HiPhorius™ 10, 40, 20L and 50L) as a zootechnical feed additive for all poultry, all Suidae and all fin fish. The FEEDAP Panel concluded that the genetic modification of the production strain does not give rise to safety concerns. Based on the no observed adverse effect level identified in a subchronic oral toxicity study in rats, the additive was considered safe for all poultry, all Suidae and all fin fish at the proposed conditions of use. The Panel also concluded that the use of the product as a feed additive is of no concern for the consumers and the environment. The liquid formulations of the additive are not skin or eye irritants. The two solid ones are not skin irritants but are eye irritants. Owing to the lack of data, the Panel cannot conclude on the skin sensitisation of the final formulations of the additive. Due to the proteinaceous nature of the active substance (6‐phytase), the additive is considered a respiratory sensitiser. The Panel concludes that the additive is efficacious when included in the diet of poultry for fattening or reared for laying/breeding, reproductive Suidae, and all fin fish. Due to the lack of sufficient data, the Panel could not conclude on the efficacy for laying and reproductive poultry and growing Suidae.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEFSA J. 2024 Mar 11;22(3):e8663. doi: 10.2903/j.efsa.2024.8663. eCollection 2024 Mar.
dc.identifier.doi10.2903/j.efsa.2024.8663pt_PT
dc.identifier.issn1831-4732
dc.identifier.pmid38469362
dc.identifier.urihttp://hdl.handle.net/10400.18/10416
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWiley-VCH Verlag
dc.relation.hasversionhttps://efsa.onlinelibrary.wiley.com/doi/full/10.2903/j.efsa.2024.8663
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectFeed Additivept_PT
dc.subjectHiPhorius™
dc.subjectDigestibility Enhancers
dc.subjectZootechnical Additives
dc.subjectSafety and Efficacypt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleSafety and efficacy of a feed additive consisting of 6‐phytase produced by Aspergillus oryzae DSM 33737 (HiPhorius™) for all poultry, all Suidae and all fin fish (DSM Nutritional Products Ltd)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue3pt_PT
oaire.citation.startPagee8663
oaire.citation.titleEFSA Journal
oaire.citation.volume22pt_PT
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameLouro
person.givenNameHenriqueta
person.identifier157627
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.orcid0000-0001-9744-7332
person.identifier.scopus-author-id6507971479
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2361a951-8b9a-4b90-92d6-f6384003a242
relation.isAuthorOfPublication.latestForDiscovery2361a951-8b9a-4b90-92d6-f6384003a242

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