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Setting up a collaborative European Human biological monitoring study on occupational exposure to Hexavalent Chromium

2019-08-29Conference object Restricted access
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dc.contributor.authorSantonen, Tiina
dc.contributor.authorAlimonti, Alessandro
dc.contributor.authorBocca, Beatrice
dc.contributor.authorDuca, Radu Corneliu
dc.contributor.authorGalea, Karen S.
dc.contributor.authorGodderis, Lode
dc.contributor.authorGöen, Thomas
dc.contributor.authorGomes, Bruno
dc.contributor.authorHanser, Ogier
dc.contributor.authorIavicoli, Ivo
dc.contributor.authorJanasik, Beata
dc.contributor.authorJones, Kate
dc.contributor.authorKiilunen, Mirja
dc.contributor.authorKoch, Holger M.
dc.contributor.authorLeese, Liz
dc.contributor.authorLeso, Veruscka
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorNdaw, Sophie
dc.contributor.authorPorras, Simo P.
dc.contributor.authorRobert, Alain
dc.contributor.authorRuggieri, Flavia
dc.contributor.authorScheepers, Paul
dc.contributor.authorSilva, Maria João
dc.contributor.authorViegas, Susana
dc.contributor.authorWasowicz, Wojciech
dc.contributor.authorCastano, Argelia
dc.contributor.authorSepai, Ovnair
dc.date.accessioned2020-06-09T11:13:58Z
dc.date.available2020-06-09T11:13:58Z
dc.date.issued2019-08-29
dc.description.abstractBackground: The EU human biomonitoring initiative, HBM4EU, aims to co-ordinate and advance human biomonitoring across Europe and develop new approaches for biomonitoring. Hexavalent chromium (Cr(VI)) is an important occupational carcinogen, which compounds are currently authorized in Europe. In addition, a binding limit value for occupational exposure to Cr(VI) has been recently agreed in EU. These regulatory actions emphasize the need for EU-wide data on exposure and sensitive biomarkers to assess the exposure. Here we describe the design of the multinational, collaborative project to support management of occupational exposure to Cr(VI). Methods: The study involves eight European countries and aims to recruit 400 workers performing Cr(VI) surface treatment or stainless steel welding. In addition to urinary chromium (U-Cr), exhaled breath condensate (EBC) and blood samples are collected for the analysis of Cr(VI)/Cr. Exposure data will be complemented with data on effect markers. Personal air and wipe samples are collected in parallel to help interpretation of biomonitoring results. Standardized questionnaires are used to collect contextual data, and samplings are done following the standard operational procedures developed to support standardization. Results: This occupational Cr(VI) study is the first that will be performed concurrently in multiple European countries using harmonized protocols for data gathering, sampling and analysis. Combining national standardized surveys the power of the study and the strength of the findings is greatly enhanced. Samplings are currently on-going and include companies ranging from micro-sized companies to large international companies. Final results are expected by the end of 2020. The presentation covers the background data on the tasks covered and the available external exposure data. Conclusions: Using this unique set-up including multiple countries and harmonized protocols we expect to create more comprehensive data for EU decision making. The data allows also the assessment of the feasibility of different biomarkers in the biomonitoring of Cr(VI).pt_PT
dc.description.sponsorshipThis project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 733032.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/6973
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.subjectHexavalent Chromiumpt_PT
dc.subjectHuman Biomonitoringpt_PT
dc.subjectOccupational Exposruept_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleSetting up a collaborative European Human biological monitoring study on occupational exposure to Hexavalent Chromiumpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.conferencePlaceLeuven, Bélgicapt_PT
oaire.citation.title11th International Symposium on Biological Monitoring in Occupational and Environmental Health (ISBM-11), 28-30 August 2019pt_PT
oaire.fundingStreamH2020
person.familyNameLouro
person.familyNameSilva
person.givenNameHenriqueta
person.givenNameMaria Joao
person.identifier157627
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0001-9744-7332
person.identifier.orcid0000-0002-6060-0716
person.identifier.scopus-author-id6507971479
person.identifier.scopus-author-id55944437600
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication2361a951-8b9a-4b90-92d6-f6384003a242
relation.isAuthorOfPublicationa7763685-7c34-468d-b958-9dd0aca66db4
relation.isAuthorOfPublication.latestForDiscovery2361a951-8b9a-4b90-92d6-f6384003a242
relation.isProjectOfPublication6815dc2d-ef7e-4535-8dd3-5193c8bffba5
relation.isProjectOfPublication.latestForDiscovery6815dc2d-ef7e-4535-8dd3-5193c8bffba5

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