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Burden of osteoporosis and costs associated with human biomonitored cadmium exposure in three European countries: France, Spain and Belgium

2021-04-13Journal article Open access
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dc.contributor.authorOugier, E.
dc.contributor.authorFiore, K.
dc.contributor.authorRousselle, C.
dc.contributor.authorAssunção, Ricardo
dc.contributor.authorMartins, C.
dc.contributor.authorBuekers, J.
dc.date.accessioned2022-07-03T14:47:52Z
dc.date.available2022-07-03T14:47:52Z
dc.date.issued2021-04-13
dc.description.abstractCadmium (Cd) is a toxic heavy metal widespread in the environment leading to human exposure in particular through diet (when smoking is excluded), as documented by recent human biomonitoring (HBM) surveys. Exposure to Cd at environmental low-exposure levels has been associated with adverse effects such as renal toxicity and more recently bone effects. The implication, even if limited, of Cd in the etiology of osteoporosis can be of high importance at the population level given the significant prevalence of osteoporosis and the ubiquitous and life-long exposure to Cd. Therefore, the osteoporosis cases attributable to Cd exposure was estimated in three European countries (Belgium, France and Spain), based on measured urinary Cd levels from HBM studies conducted in these countries. The targeted population was women over 55 years old, for which risk levels associated with environmental Cd exposure were available. Around 23% of the cases were attributed to Cd exposure. Moreover, in a prospective simulation approach of lifelong urinary Cd concentrations assuming different intakes scenarios, future osteoporosis attributable cases were calculated, based on urinary Cd levels measured in women aged under 55. Between 6 and 34% of the considered populations under 55 years were at risk for osteoporosis. Finally, the costs associated to the burden of osteoporosis-related fractures attributable to Cd for each country targeted in this paper were assessed, standing for a major contributing role of Cd exposure in the overall social costs related to osteoporosis. Absolute costs ranged between 0.12 (low estimate in Belgium) and 2.6 billion Euros (high estimate in France) in women currently over 55 years old and at risk for fractures. Our results support the importance of reducing exposure of the general population to Cd.pt_PT
dc.description.sponsorshipThe authors received funding from the EU Horizon2020 Framework Project, HBM4EU, Grant number 733032.Our thanks to FCT/MCTES for the financial support to CESAM (UIDP/50017/2020+UIDB/50017/2020), through national funds.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J Hyg Environ Health. 2021 May;234:113747. doi: 10.1016/j.ijheh.2021.113747. Epub 2021 Apr 13.pt_PT
dc.identifier.doi10.1016/j.ijheh.2021.113747pt_PT
dc.identifier.issn1438-4639
dc.identifier.urihttp://hdl.handle.net/10400.18/8043
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier/ Urban and Fischerpt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.relationCentre for Environmental and Marine Studies
dc.relationCentre for Environmental and Marine Studies
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1438463921000626?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectHuman Biomonitoring (HBM)pt_PT
dc.subjectHBM4EUpt_PT
dc.subjectCadmium (Cd)pt_PT
dc.subjectDisease Burdenpt_PT
dc.subjectOsteoporosispt_PT
dc.subjectPopulation Attributable Fractionpt_PT
dc.subjectDisability-adjusted Life Year (DALY)/Qualityadjusted life year (QALY)pt_PT
dc.subjectEuropept_PT
dc.subjectSegurança Alimentarpt_PT
dc.subjectComposição dos Alimentospt_PT
dc.subjectAvaliação do Riscopt_PT
dc.subjectToxicologia dos Alimentospt_PT
dc.titleBurden of osteoporosis and costs associated with human biomonitored cadmium exposure in three European countries: France, Spain and Belgiumpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50017%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50017%2F2020/PT
oaire.citation.startPage113747pt_PT
oaire.citation.titleInternational Journal of Hygiene and Environmental Healthpt_PT
oaire.citation.volume234pt_PT
oaire.fundingStreamH2020
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication6815dc2d-ef7e-4535-8dd3-5193c8bffba5
relation.isProjectOfPublication4e22de31-8fc5-4b15-b980-3fd0edf5515d
relation.isProjectOfPublication0e72e6c8-b610-43e0-931c-8ad275ad6093
relation.isProjectOfPublication.latestForDiscovery6815dc2d-ef7e-4535-8dd3-5193c8bffba5

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