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New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals - a PARC (Partnership for the Assessment of Risk from Chemicals) project

2024-04-09Artigo de investigação Acesso aberto
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datacite.subject.fosCiências Naturais
dc.contributor.authorSnapkow, Igor
dc.contributor.authorSmith, Nicola M.
dc.contributor.authorArnesdotter, Emma
dc.contributor.authorBeekmann, Karsten
dc.contributor.authorBlanc, Etienne B.
dc.contributor.authorBraeuning, Albert
dc.contributor.authorCorsini, Emanuela
dc.contributor.authorSollner Dolenc, Marija
dc.contributor.authorDuivenvoorde, Loes P.M.
dc.contributor.authorSundstøl Eriksen, Gunnar
dc.contributor.authorFranko, Nina
dc.contributor.authorGalbiati, Valentina
dc.contributor.authorGostner, Johanna M.
dc.contributor.authorGrova, Nathalie
dc.contributor.authorGutleb, Arno C.
dc.contributor.authorHargitai, Rita
dc.contributor.authorJanssen, Aafke W.F.
dc.contributor.authorKrapf, Solveig A.
dc.contributor.authorLindeman, Birgitte
dc.contributor.authorLumniczky, Katalin
dc.contributor.authorMaddalon, Ambra
dc.contributor.authorMollerup, Steen
dc.contributor.authorParráková, Lucia
dc.contributor.authorPierzchalski, Arkadiusz
dc.contributor.authorPieters, Raymond H.H.
dc.contributor.authorSilva, Maria Joao
dc.contributor.authorSolhaug, Anita
dc.contributor.authorStaal, Yvonne C.M.
dc.contributor.authorStraumfors, Anne
dc.contributor.authorSzatmári, Tünde
dc.contributor.authorTurner, Jonathan D.
dc.contributor.authorVandebriel, Rob J.
dc.contributor.authorZenclussen, Ana Claudia
dc.contributor.authorBarouki, Robert
dc.date.accessioned2025-03-20T15:50:09Z
dc.date.available2025-03-20T15:50:09Z
dc.date.issued2024-04-09
dc.description.abstractAs a complex system governing and interconnecting numerous functions within the human body, the immune system is unsurprisingly susceptible to the impact of toxic chemicals. Toxicants can influence the immune system through a multitude of mechanisms, resulting in immunosuppression, hypersensitivity, increased risk of autoimmune diseases and cancer development. At present, the regulatory assessment of the immunotoxicity of chemicals relies heavily on rodent models and a limited number of Organisation for Economic Co-operation and Development (OECD) test guidelines, which only capture a fraction of potential toxic properties. Due to this limitation, various authorities, including the World Health Organization and the European Food Safety Authority have highlighted the need for the development of novel approaches without the use of animals for immunotoxicity testing of chemicals. In this paper, we present a concise overview of ongoing efforts dedicated to developing and standardizing methodologies for a comprehensive characterization of the immunotoxic effects of chemicals, which are performed under the EU-funded Partnership for the Assessment of Risk from Chemicals (PARC).
dc.description.sponsorshipThis project is funded by the European Partnership for the Assessment of Risks from Chemicals (PARC) under the Horizon Europe Research and Innovation Programme, Grant Agreement No. 101057014.
dc.identifier.citationFront Toxicol. 2024 Apr 9:6:1339104. doi: 10.3389/ftox.2024.1339104. eCollection 2024. Review
dc.identifier.doi10.3389/ftox.2024.1339104
dc.identifier.issn2673-3080
dc.identifier.pmid38654939
dc.identifier.urihttp://hdl.handle.net/10400.18/10452
dc.language.isoeng
dc.peerreviewedyes
dc.publisherFrontiers Media
dc.relationEuropean Partnership for the Assessment of Risks from Chemicals (PARC)
dc.relation.hasversionhttps://www.frontiersin.org/journals/toxicology/articles/10.3389/ftox.2024.1339104/full
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectNAMs
dc.subjectPARC
dc.subjectchemical toxicology
dc.subjectimmunosuppression
dc.subjectimmunotoxicology
dc.subjectnew approach methodologies
dc.subjectregulatory toxicology
dc.subjectgenotoxicidade ambiental
dc.subjectenvironmental genotoxicity
dc.titleNew approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals - a PARC (Partnership for the Assessment of Risk from Chemicals) projectpor
dc.typeresearch article
dspace.entity.typePublication
oaire.awardTitleEuropean Partnership for the Assessment of Risks from Chemicals (PARC)
oaire.awardURIhttp://hdl.handle.net/10400.18/10383
oaire.citation.startPage1339104
oaire.citation.titleFrontiers in Toxicology
oaire.citation.volume6
oaire.fundingStreamHorizon Europe Guarantee
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameSilva
person.givenNameMaria Joao
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0002-6060-0716
person.identifier.scopus-author-id55944437600
relation.isAuthorOfPublicationa7763685-7c34-468d-b958-9dd0aca66db4
relation.isAuthorOfPublication.latestForDiscoverya7763685-7c34-468d-b958-9dd0aca66db4
relation.isProjectOfPublicationa7df9a6a-838e-406c-94c7-1baa7daba05c
relation.isProjectOfPublication.latestForDiscoverya7df9a6a-838e-406c-94c7-1baa7daba05c

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