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Serum 25-hydroxyvitamin D levels in multiple sclerosis patients from the north of Portugal

2017-09-22Journal article Restricted access
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dc.contributor.authorBettencourt, Andreia
dc.contributor.authorBoleixa, Daniela
dc.contributor.authorReguengo, Henrique
dc.contributor.authorSamões, Raquel
dc.contributor.authorSantos, Ernestina
dc.contributor.authorOliveira, José Carlos
dc.contributor.authorSilva, Berta
dc.contributor.authorCosta, Paulo Pinho
dc.contributor.authorda Silva, Ana Martins
dc.date.accessioned2018-03-08T12:17:31Z
dc.date.available2018-03-08T12:17:31Z
dc.date.issued2017-09-22
dc.description.abstractIncreasing evidence has shown that individuals with Multiple Sclerosis (MS) have lower 25-hydroxyvitamin D [25(OH)D] levels compared to healthy controls. There is no information regarding 25(OH)D levels and MS in Portugal. Therefore the aim of the current study was to examine the levels of 25(OH)D in a group of patients with MS and in healthy matched controls, as well as the association of 25(OH)D levels with disease course, disability and severity. A group of 244 unrelated Portuguese patients, with a definitive diagnosis of MS, and 198 ethnically matched healthy controls were included in the study. A sub-group of patients with recent disease onset was included. Serum 25(OH)D was measured using an electrochemiluminescence binding assay. The mean serum level of 25(OH)D in patients with MS was 39.9±22.0 nmol/L, which was significantly lower (p<0.0001) than those in healthy controls, 55.4±23.4 nmol/L. There was a negative correlation between 25(OH)D levels and EDSS (r=-0.293, p<0.0001) and MSSS scores (r=-0.293, p<0.0001). In multiple logistic regression analysis adjusted for age, gender, disease form, EDSS, disease duration and MSSS, 25(OH)D levels were independently associated with EDSS (p=0.004) and disease duration (p=0.016), and with MSSS (p=0.001). In accordance with the majority of the literature, low serum 25(OH)D levels were associated with susceptibility and disability in MS patients from Portugal. Lower serum 25(OH)D levels were also found in patients with a recent disease onset, supporting vitamin D levels as a risk factor for MS.pt_PT
dc.description.sponsorshipAndreia Bettencourt has received a PhD grant (SFRH/BD/112355/2015) from National Funds through the FCT − Fundação para a Ciência e a Tecnologia (Portuguese national funding agency for science, research and technology) in the frameworks of the UID/Multi/00215/2013 project − Unit for Multidisciplinary Research in Biomedicine − UMIB/ICBAS/UP. The study of serum 25(OH)D levels in a healthy population from the North of Portugal, included in this work, was supported by Merck S.A.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Steroid Biochem Mol Biol. 2018 Jun;180:137-141. doi: 10.1016/j.jsbmb.2017.09.016. Epub 2017 Sep 22.pt_PT
dc.identifier.doi10.1016/j.jsbmb.2017.09.016pt_PT
dc.identifier.issn0960-0760
dc.identifier.urihttp://hdl.handle.net/10400.18/5367
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0960076017302649?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subject25(OH)Dpt_PT
dc.subjectDisabilitypt_PT
dc.subjectMultiple Sclerosispt_PT
dc.subjectVitamin Dpt_PT
dc.subjectPortugalpt_PT
dc.subjectSusceptibilitypt_PT
dc.subject:Dermatology and Venerologypt_PT
dc.subjectClinical Geneticspt_PT
dc.subjectInternal Medicinept_PT
dc.subjectNeurologypt_PT
dc.subjectDoenças Genéticaspt_PT
dc.titleSerum 25-hydroxyvitamin D levels in multiple sclerosis patients from the north of Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00215%2F2013/PT
oaire.citation.titleJournal of Steroid Biochemistry and Molecular Biologypt_PT
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication72dac09a-7aa0-495e-ba34-d427d0237e8f
relation.isProjectOfPublication.latestForDiscovery72dac09a-7aa0-495e-ba34-d427d0237e8f

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