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Tuberculosis: new aspects of an old disease
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Tuberculosis is an ancient infectious disease that remains a threat for public health around the world. Although the etiological agent
as well as tuberculosis pathogenesis is well known, the molecular mechanisms underlying the host defense to the bacilli remain
elusive. In this paper we focus on the innate immunity of this disease reviewing well-established and consensual mechanisms like
Mycobacterium tuberculosis interference with phagosomematuration, less consensual mechanism like nitric oxide production, and
new mechanisms, such as mycobacteria translocation to the cytosol, autophagy, and apoptosis/necrosis proposed mainly during
the last decade.
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Citação
Int J Cell Biol. 2011;2011:403623. Epub 2011 Jun 21