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Systematic review and modelling of seroprevalence in humans, Europe, 2000 to 2021

2025-08-28Artigo científico Acesso aberto
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datacite.subject.fosCiências Médicas::Ciências da Saúde
dc.contributor.authorFriesema, Ingrid Hm
dc.contributor.authorWaap, Helga
dc.contributor.authorSwart, Arno
dc.contributor.authorGyörke, Adriana
dc.contributor.authorLe Roux, Delphine
dc.contributor.authorEvangelista, Francisco Md
dc.contributor.authorSpano, Furio
dc.contributor.authorSchares, Gereon
dc.contributor.authorDeksne, Gunita
dc.contributor.authorGargaté, Maria João
dc.contributor.authorCalero-Bernal, Rafael
dc.contributor.authorJokelainen, Pikka
dc.contributor.authorSeeber, Frank
dc.contributor.authorSroka, Jacek
dc.contributor.authorLundén, Anna
dc.contributor.authorvan den Berg, Oda
dc.contributor.authorJore, Solveig
dc.contributor.authorWisselink, Henk J.
dc.contributor.authorDámek, Filip
dc.contributor.authorVestergaard, Lasse S.
dc.contributor.authorOpsteegh, Marieke
dc.contributor.editorAPAGAR
dc.date.accessioned2026-02-13T11:42:45Z
dc.date.available2026-02-13T11:42:45Z
dc.date.issued2025-08-28
dc.description.abstractBackground: Toxoplasma gondii is a zoonotic protozoan capable of infecting warm-blooded animal species and humans. Although toxoplasmosis presents mostly as mild or asymptomatic infection in immunocompetent individuals, in unborn children and people with weakened immune systems, the disease can be severe with ocular, neurological or multi-systemic manifestations and even death. Aim: We aimed to collate and analyse data on T. gondii seroprevalence in humans to model and compare age-dependent prevalence in geographic regions in Europe. Methods: A systematic review identified 1,822 scientific publications, from which seroprevalence data were extracted from 69 studies. Data were analysed using a Bayesian hierarchical model. Results: The modelling of the seroprevalence indicated the highest incidence rates in eastern (50%) and western (48%) Europe, with the lowest estimates in northern Europe (18%) and the United Kingdom (UK) (18%). Eastern and western Europe were regions where T. gondii infections occurred earliest in life, with half of the population expected to be seropositive by the age of 44 and 47 years, respectively. In contrast, in northern Europe and the UK the modelled median time to infection exceeded 170 years. Conclusions: Results of the study provide a robust baseline for future epidemiological research on human T. gondii infections in Europe and may be useful to validate subsequent research, such as risk assessment studies.eng
dc.description.sponsorshipThis work was performed within the projects TOXOSOURCES and ToxSauQMRA that received funding from the European Union’s Horizon 2020 Research and Innovation Programme, under grant agreement No. 773830: One Health European Joint Programme.
dc.identifier.citationEuro Surveill. 2025 Aug;30(34):2500069. doi: 10.2807/1560-7917.ES.2025.30.34.2500069
dc.identifier.doi10.2807/1560-7917.ES.2025.30.34.2500069
dc.identifier.eissn1025-496X
dc.identifier.issn1560-7917
dc.identifier.pmid40878705
dc.identifier.urihttp://hdl.handle.net/10400.18/10930
dc.language.isoeng
dc.peerreviewedyes
dc.publisherEuropean Centre for Disease Prevention and Control
dc.relationPromoting One Health in Europe through joint actions on foodborne zoonoses, antimicrobial resistance and emerging microbiological hazards.
dc.relation.hasversionhttps://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2025.30.34.2500069
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectToxoplasma gondii
dc.subjectSeroprevalence
dc.subjectHuman
dc.subjectEurope
dc.subjectSystematic Review
dc.subjectInfecções Sistémicas e Zoonoses
dc.titleSystematic review and modelling of seroprevalence in humans, Europe, 2000 to 2021eng
dc.typejournal article
dcterms.referenceshttps://pmc.ncbi.nlm.nih.gov/articles/instance/12397722/bin/25-00069_FRIESEMA_Supplement.pdf
dspace.entity.typePublication
oaire.awardTitlePromoting One Health in Europe through joint actions on foodborne zoonoses, antimicrobial resistance and emerging microbiological hazards.
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/773830/EU
oaire.citation.issue34
oaire.citation.startPage2500069
oaire.citation.titleEurosurveillance: Europe's journal on infectious disease surveillance, epidemiology, prevention and control
oaire.citation.volume30
oaire.fundingStreamH2020
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
relation.isProjectOfPublication94d118fb-33ce-49fa-b1ed-d5bddf63581d
relation.isProjectOfPublication.latestForDiscovery94d118fb-33ce-49fa-b1ed-d5bddf63581d

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