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Influence of interleukin-6 gene polymorphisms in epicardial adipose tissue and coronary artery calcification in patients with psoriasis

2014-12-30Journal article Restricted access
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dc.contributor.authorTorres, T.
dc.contributor.authorBettencourt, N.
dc.contributor.authorFerreira, J.
dc.contributor.authorCarvalho, C.
dc.contributor.authorMendonça, D.
dc.contributor.authorPinho-Costa, P.
dc.contributor.authorVasconcelos, C.
dc.contributor.authorSelores, M.
dc.contributor.authorSilva, B.
dc.date.accessioned2015-02-17T13:32:19Z
dc.date.available2015-02-17T13:32:19Z
dc.date.issued2014-12-30
dc.descriptionResearch letterpor
dc.description.abstractPsoriasis is currently considered a systemic inflammatory disorder associated with several comorbidities and increased risk of cardiovascular disease (CVD)1 cytokines are overexpressed cutaneous and systemically and may be responsible for skin lesions but also for psoriasis-associated conditions surrounding the heart, is now regarded as an important factor in the pathogenesis of coronary atherosclerosis and CVD, through inflammatory burden proximal to the coronary arteries, and has been shown to be increased in psoriasis patients independently of abdominal visceral fat (AVF) and to be associated with sub-clinical atherosclerosis IL-6 has been implicated in the pathogenesis of psoriasis1 but also of abdominal obesity atherosclerosis and CVD4 30% of total circulating concentrations in healthy subjects thought to be influenced by polymorphisms in their gene loci, and this may contribute to the development of psoriasis, but also excess adiposity and psoriasis has been investigated that could predict which patients are at risk of developing psoriasis-linked cardiovascular comorbidities may permit an earlier management, with important clinical implications. This study aimed to evaluate the potential contribution of four IL-6 genetic variants (rs1800795[-174G>C], rs1800796[-572G>C], rs2069827[-1426G>T], rs2069840[-1753C>G]) in psoriasis susceptibility and its influence in EAT and coronary artery calcification (CAC) in severe psoriasis patients.por
dc.identifier.citationBr J Dermatol. 2015 Feb;172(2):534-6. doi: 10.1111/bjd.13271. Epub 2014 Dec 30por
dc.identifier.doi10.1111/bjd.13271
dc.identifier.issn0007-0963
dc.identifier.urihttp://hdl.handle.net/10400.18/2870
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherWiley/ British Association of Dermatologistspor
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1111/bjd.13271/fullpor
dc.subjectIL-6 gene Polymorphismspor
dc.subjectEpicardial Adipose Tissuepor
dc.subjectPsoriasispor
dc.subjectDoenças Genéticaspor
dc.titleInfluence of interleukin-6 gene polymorphisms in epicardial adipose tissue and coronary artery calcification in patients with psoriasispor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage536por
oaire.citation.startPage534por
oaire.citation.titleBritish Journal of Dermatologypor
oaire.citation.volume172(2)por
rcaap.rightsembargoedAccesspor
rcaap.typearticlepor

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