Logo do repositório
 
Publicação

Distinct exercise modalities on GUT microbiome in sarcopenic older adults: study protocol of a pilot randomized controlled trial

2025-03-05Artigo científico Acesso aberto
Ver registo simples
datacite.subject.fosCiências Médicas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorMerelim, Ana Sofia
dc.contributor.authorZacca, Rodrigo
dc.contributor.authorMoreira-Gonçalves, Daniel
dc.contributor.authorCosta, Paulo P.
dc.contributor.authorC. Baptista, Liliana
dc.date.accessioned2026-02-16T09:58:48Z
dc.date.available2026-02-16T09:58:48Z
dc.date.issued2025-03-05
dc.description(This article is part of the Research Topic: Spotlight on Aging: Role of Exercise and Nutrition in Healthy Longevity)
dc.description.abstractBackground: Sarcopenia is a progressive and age-related skeletal muscle disease related to adverse health outcomes and to an increased economic burden. Recent evidence pinpoints the human gut microbiota (GM) as a contributing factor in the development of sarcopenia via the gut-muscle axis. To date, no study specifically analyzed the optimal type of exercise modality in older adults with sarcopenia considering the impact of GM composition in skeletal muscle mass and function. Therefore, the DEMGUTS study intents to explore the impact of three different exercise regimens on GM composition and gut-derived metabolites in older adults with sarcopenia. Methods:: This pilot single center three-arm parallel open-label randomized control trial (RCT) will randomly assign eligible participants to: (i) moderate aerobic exercise (AER); (ii) resistance exercise (RES); or (iii) concurrent exercise training (RES + AER). Participants will engage in a supervised center-based exercise intervention (12-weeks, 3 d/week, 60 min/d), and will be assessed at (i) baseline, (ii) end of intervention (14 weeks), and (iii) at close-out (26-weeks). The primary outcome will be the change in the relative abundance of Faecalibacterium prausnitzi and other short-chain fatty acid producing bacteria after the intervention (14-weeks). A set of complementary outcomes will also be assessed to broadly characterize the impact of each exercise intervention on body composition, skeletal muscle function, functional performance and general GM composition. Conclusion: Unraveling the impact of these exercise regimens on GM is crucial to help clarify the optimal exercise modality to manage sarcopenia disease, contributing to clinical guidance and enhancing exercise prescription in older adults with sarcopenia. Clinical trial registration identifier NCT06545123eng
dc.description.sponsorshipThis study was supported by a grant from the Portuguese Foundation for Science and Technology [UIDB/04750/2020 (DOI:10.54499/UIDB/04750/2020)] and the Laboratory for Integrative and Translational Research in Population Health [LA/P/0064/2020 (DOI:10.54499/LA/P/0064/2020)]
dc.identifier.citationFront Med (Lausanne). 2025 Mar 5:12:1504786. doi: 10.3389/fmed.2025.1504786. eCollection 2025
dc.identifier.doi10.3389/fmed.2025.1504786
dc.identifier.issn2296-858X
dc.identifier.pmid40109720
dc.identifier.urihttp://hdl.handle.net/10400.18/10939
dc.language.isoeng
dc.peerreviewedyes
dc.publisherFrontiers Media
dc.relationEpidemiology Research Unit - Institute of Public Health, University of Porto
dc.relationLaboratory for Integrative and Translational Research in Population Health
dc.relationLA/P/0064/2020
dc.relation.hasversionhttps://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1504786/full
dc.relation.ispartofFrontiers in Medicine
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMuscle Quantity
dc.subjectMuscle Quality
dc.subjectAerobic Exercise
dc.subjectResistance Exercise
dc.subjectConcurrent Excercise
dc.subjectGut Microbiota
dc.subjectSarcopenia
dc.subjectOlder Adults
dc.subjectDoenças Genéticas
dc.titleDistinct exercise modalities on GUT microbiome in sarcopenic older adults: study protocol of a pilot randomized controlled trialeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEpidemiology Research Unit - Institute of Public Health, University of Porto
oaire.awardTitleLaboratory for Integrative and Translational Research in Population Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04750%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0064%2F2020/PT
oaire.citation.startPage1504786
oaire.citation.titleFrontiers in Medicine
oaire.citation.volume12
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isProjectOfPublication05f4f337-eeba-4c07-82ed-4202b21618a2
relation.isProjectOfPublication18ca3cb0-ef66-4dd8-b45e-4cb0654cd7e8
relation.isProjectOfPublication.latestForDiscovery05f4f337-eeba-4c07-82ed-4202b21618a2

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
PPC_1.pdf
Tamanho:
789.99 KB
Formato:
Adobe Portable Document Format
Ver/Abrir
Licença
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
license.txt
Tamanho:
4.03 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Ver/Abrir

Coleções

DGH - Artigos em revistas internacionais
INSA - Artigos em revistas internacionais