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Physiologically based toxicokinetic models in aggregate exposure: A review

2025-09-13Journal article Restricted access
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dc.contributor.authorLamon, L.
dc.contributor.authorPaini, A.
dc.contributor.authorSiccardi, M.
dc.contributor.authorDoyle, J.
dc.contributor.authorMcNamara, C.
dc.contributor.authorGalea, K.S.
dc.contributor.authorGhosh, M.
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorSilva, Maria Joao
dc.contributor.authorEl Yamani, N.
dc.contributor.authorDusinska, M.
dc.contributor.authorMoeller, R.
dc.contributor.authorDuca, R.C.
dc.contributor.authorCubadda, F.
dc.contributor.authorViegas, S.
dc.contributor.authorMartins, C.
dc.contributor.authorPrice, P.
dc.date.accessioned2025-11-10T14:41:37Z
dc.date.available2025-11-10T14:41:37Z
dc.date.issued2025-09-13
dc.description.abstractThis literature review explores the application of Physiologically Based Kinetic (PBK) models in aggregate exposure (AE) assessment across different chemical classes. It builds on the screening of 1119 publications and the identification of 40 relevant articles. The most frequently studied chemicals include volatile organic compounds and plant protection products, with metals, personal care products, persistent organic pollutants and plasticisers also represented. Most studies reported in this review are applied to human populations and build on human biomonitoring (HBM) data to enhance model reliability. However, some studies use animal models (primarily rat models) and apply cross-species extrapolation to the human AE scenario. Occupational exposure is taken into consideration as part of the AE scenario in a few studies. Many of the reviewed studies are designed in support of chemical risk assessment (CRA), illustrating the wide applicability of PBK models. The review discusses the joint role of HBM data and PBK model in AE scenarios, highlighting its importance for a reliable risk assessments. The studies identified and discussed in this review suggest a broad interpretation of AE. The diversity across case reported studies is attributed to varying interpretations and existing definitions of AE. Finally, the roles of forward and reverse dosimetry in refining AE assessments are discussed, highlighting their importance for future research. This scoping review provides a comprehensive overview of PBK model applications in addressing AE, serving as a valuable foundation for future research and development aimed at advancing human health protection towards the Next-Generation Risk Assessment (NGRA).eng
dc.description.abstractHighlights: - Aggregate exposure is key to comprehensive chemical risk assessment: - Physiologically based kinetic models are applied to aggregate exposure using diverse approaches; - The use of human biomonitoring data and physiologically based kinetic models can enhance aggregate exposure and risk assessment.eng
dc.description.sponsorshipThis research work was partially funded by the European Food Safety Authority (EFSA) under the contract agreement (OC/EFSA/ED/2022/04) to deliver the ExpoAdvance roadmap.
dc.identifier.citationToxicol Lett. 2025 Nov:413:111725. doi: 10.1016/j.toxlet.2025.111725. Epub 2025 Sep 13
dc.identifier.doi10.1016/j.toxlet.2025.111725
dc.identifier.eissn1879-3169
dc.identifier.issn0378-4274
dc.identifier.pmid40953653
dc.identifier.urihttp://hdl.handle.net/10400.18/10578
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationOC/EFSA/ED/2022/04
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S0378427425026712?via%3Dihub
dc.relation.ispartofToxicology Letters
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAggregate Exposure
dc.subjectCombined Exposure
dc.subjectPBK
dc.subjectPBTK
dc.subjectPBPK
dc.subjectForward Dosimetry
dc.subjectReverse Dosimetry
dc.subjectInternal Exposure
dc.subjectGenotoxicidade Ambiental
dc.titlePhysiologically based toxicokinetic models in aggregate exposure: A revieweng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage111725
oaire.citation.titleToxicology Letters
oaire.citation.volume413
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameLouro
person.familyNameSilva
person.givenNameHenriqueta
person.givenNameMaria Joao
person.identifier157627
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0001-9744-7332
person.identifier.orcid0000-0002-6060-0716
person.identifier.scopus-author-id6507971479
person.identifier.scopus-author-id55944437600
relation.isAuthorOfPublication2361a951-8b9a-4b90-92d6-f6384003a242
relation.isAuthorOfPublicationa7763685-7c34-468d-b958-9dd0aca66db4
relation.isAuthorOfPublication.latestForDiscovery2361a951-8b9a-4b90-92d6-f6384003a242

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