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Relationship between DNA damage measured by the comet-assay and cognitive function

2022-11Journal article Open access
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dc.contributor.authorLorenzo-López, Laura
dc.contributor.authorLema-Arranz, Carlota
dc.contributor.authorFernández-Bertólez, Natalia
dc.contributor.authorCosta, Solange
dc.contributor.authorCosta, Carla
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorPásaro, Eduardo
dc.contributor.authorValdiglesias, Vanessa
dc.contributor.authorLaffon, Blanca
dc.date.accessioned2023-02-13T12:50:22Z
dc.date.available2023-02-13T12:50:22Z
dc.date.issued2022-11
dc.description.abstractRecent studies exploring the relationship between DNA damage measured by the comet assay (single-cell gel electrophoresis) and cognitive function in both animal models and humans are reviewed and summarized. This manuscript provides an overview of studies exploring cognitive dysfunction related to DNA damage due to biological ageing process, cancer treatment, adverse environmental or occupational exposures, and prenatal genotoxic exposure. The review confirms the potential of comet assay to further explore the link between DNA damage, as indicative of genomic instability, and cognitive impairment in different research and clinical areas. Analysed studies support, in fact, the significant relationship between DNA damage and cognitive impairment, mainly affecting attention, working memory and executive functions. These cognitive domains are crucial to daily functioning and occupational performance, with important clinical implications. Although evidence support the relationship between DNA damage measured by the comet assay and cognitive function in different settings, further longitudinal research is needed to disentangle the temporal relationship between them over time, and to explore the potential of comet assay-detected DNA lesions to predict response to interventions.pt_PT
dc.description.abstractHighlights: Review on the link between DNA damage measured by the comet-assay and cognition; Ageing, cancer treatment, hazardous exposures and prenatal DNA damage are included; Studies support association affecting attention, memory and executive functions; Further longitudinal research will help to prevent and delay cognitive decline.pt_PT
dc.description.sponsorshipThis work was funded by the Spanish Ministry of Science and Innovation: MCIN/AEI/10.13039/501100011033 [Grant PID2020- 113788RB-I00], Xunta de Galicia (ED431B 2022/16, ED431F 2017/09), Ministry of Education, Culture and Sport [BEAGAL18/00142 to V.V.], and Ministry of Economy and Competitiveness, co-financed by the European Social Fund [RYC-2015–18394 to L.L-L]. Funding for open access charge: Universidade da Coruna/CISUG.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMutat Res Genet Toxicol Environ Mutagen. 2022 Nov-Dec;883-884:503557. doi: 10.1016/j.mrgentox.2022.503557. Epub 2022 Oct 7pt_PT
dc.identifier.doi10.1016/j.mrgentox.2022.503557pt_PT
dc.identifier.issn1383-5718
dc.identifier.urihttp://hdl.handle.net/10400.18/8524
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S138357182200119X?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCognitive Performancept_PT
dc.subjectComet Assaypt_PT
dc.subjectDNA Damagept_PT
dc.subjectOxidative DNA Damagept_PT
dc.subjectRisk Factorspt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleRelationship between DNA damage measured by the comet-assay and cognitive functionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage503557pt_PT
oaire.citation.titleMutation Research/Genetic Toxicology and Environmental Mutagenesispt_PT
oaire.citation.volume883-884pt_PT
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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