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Torch Group Infections: a possible cause of cerebral palsy

2019-05-23Conference object Restricted access
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dc.contributor.authorCadete, Ana
dc.contributor.authorVirella, Daniel
dc.contributor.authorFolha, Teresa
dc.contributor.authorCalado, Eulália
dc.contributor.authorGaia, Teresa
dc.contributor.authorGouveia, Rosa
dc.contributor.authorAlvarelhão, José
dc.contributor.authorAndrada, Maria da Graça
dc.contributor.authorNational Surveillance of Cerebral Palsy in Portugal
dc.date.accessioned2020-05-21T11:18:56Z
dc.date.available2020-05-21T11:18:56Z
dc.date.issued2019-05-23
dc.description.abstractIntroduction - TORCH infections are a cause of severe disorders in the foetus and newborn and may be associated to cerebral palsy (CP). Their importance was evaluated concerning aetiology, clinical presentation, evolution and intervention in children in CP Patients and methods: The National Portuguese Surveilllance of Cerebral Palsy at five years of age (PSCP5YA) systematically registers children with PC born since 2001. The definition and classification of Surveillance of Cerebral Palsy in Europe (SCPE) are used. Clinical and functional characterization as well as risk factors for CP was carried out in children born 2001-2010 comparing cases with TORCH infection (definition TORCHnet) with the remainder. Results: 70 cases out off 1193 (6%) were identified: CMV 44, HIV 13, syphilis 6 and CMV+VIH 2. Bilateral spastic CP predominated (71% vs 53%). Functional impairment is significantly more severe (GMFCS, BMFM, cognition and Viking Speech Scale), comorbidities more frequent (epilepsy, severe neurossensorial handicap). The MRI shows a greater percentage of brain malformations (40% vs 12%) and more miscellaneous cases (33% vs 10%) with rare cases of normal MRI (2,5% vs 5,7%). PC associated with TORCH infection is significantly associated with term/near term delivery, mother’s age < 20, small for gestational age (SGA), Apgar score < 6, less seizures in first 72 hours and less admissions in Neonatal Units. Conclusions: TORCH infections are relatively frequent in children with CP. Although neonatal presentation appears to be less severe is increased at 5 years of age. It is recommended to look for TORCH infection in children with CP or high suspicion of CP without known risk factors , born at term or near term, SGA, in young mothers and with encephalous malformations.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/6737
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherInstituto Nacional de Saúde Doutor Ricardo Jorge, IPpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectTORCH Infectionpt_PT
dc.subjectCerebral Palsypt_PT
dc.subjectSeveritypt_PT
dc.subjectEstados de Saúde e de Doençapt_PT
dc.subjectPrograma Vigilância Nacional da Paralisia Cerebralpt_PT
dc.titleTorch Group Infections: a possible cause of cerebral palsypt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceParis, Françapt_PT
oaire.citation.title31st Annual meeting of the European Academy of Childhood Disability (EACD), 23-25 May 2019pt_PT
person.familyNameVirella
person.familyNamefolha
person.familyNameMarques Alvarelhão
person.familyNameAndrada
person.givenNameDaniel
person.givenNameteresa
person.givenNameJosé Joaquim
person.givenNameMaria da Graça
person.identifierhttps://scholar.google.com/citations?hl=pt-PT&user=ZuoM2qkAAAAJ
person.identifier.ciencia-id261A-49B5-9F1A
person.identifier.ciencia-id4014-D89A-5C77
person.identifier.orcid0000-0002-5952-5632
person.identifier.orcid0000-0002-0437-2675
person.identifier.orcid0000-0002-4564-4323
person.identifier.orcid0000-0001-8439-0867
person.identifier.scopus-author-id6602564757
person.identifier.scopus-author-id55387623300
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication6958a884-7567-4b3d-ab3b-9cde279541f3
relation.isAuthorOfPublicationc449c091-7b6a-47c5-94fe-358fcb011291
relation.isAuthorOfPublication1a754284-475b-4bf8-a9a5-01ad6e681c4f
relation.isAuthorOfPublication37ee79cc-e290-455f-a5bc-fe3a8db22ee6
relation.isAuthorOfPublication.latestForDiscovery1a754284-475b-4bf8-a9a5-01ad6e681c4f

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