Repository logo
 
Publication

Differences in the genotype frequencies of genes related to blood pressure regulation - a comparative study between South-West Europe and Peri-equatorial Africa

2021-12-14Journal article Open access
Simple item page
dc.contributor.authorAguiar, Laura
dc.contributor.authorSemente, Ildegário
dc.contributor.authorFerreira, Joana
dc.contributor.authorCarvalho, Andreia
dc.contributor.authorSilva, Alda P.
dc.contributor.authorCaroça, Cristina
dc.contributor.authorCaria, Helena
dc.contributor.authorDamasceno, Albertino
dc.contributor.authorLaires, Maria J.
dc.contributor.authorSardinha, Luís
dc.contributor.authorMonteiro, Cristina
dc.contributor.authorMascarenhas, Mário R.
dc.contributor.authorFaustino, Paula
dc.contributor.authorInácio, Ângela
dc.contributor.authorBicho, Manuel
dc.date.accessioned2022-02-02T16:59:26Z
dc.date.available2022-02-02T16:59:26Z
dc.date.issued2021-12-14
dc.description.abstractBackground: Since the emergence of the genus Homo, hominids have occupied a wide variety of environments, facing different selective pressures. Objectives: The aim this study is to compare genotype frequencies between South-West Europe and Peri-equatorial Africa in genes potentially modulators of blood pressure. Methods: The analyzed sample consisted of 325 individuals from Portugal and 226 individuals from Africa (48 from Mo zambique and 178 from São Tomé and Príncipe). The following genetic variants were analyzed: intron 4 VNTR in eNOS, rs1050829 in G6PD, -3.7kb α-thalassemic deletion in HBA, rs1800457 in CYB5R3, Hp 1/2 genotype/phenotype in Hp and intron 16 I/D in ACE. Results: Frequencies of genotypes with the 4a allele in eNOS (p<0.001), the G allele in G6PD (p<0.001), the α-3.7 kb in HBA (p <0.001), the C allele in the CYB5R3 (p<0.001) were higher in Peri-equatorial Africa. The Hp 1.1 genotype of Hp has a higher frequency in Peri-equatorial Africa (p=0.002). ACE shows no significant differences. Conclusion: Results show differences in five genetic variants. Conditions of extreme heat and humidity, characteristic of Peri-equatorial Africa, have been associated with increased sodium loss. This study suggests that selected compensatory mechanisms printed in the genome, are nowadays risk factors for hypertension in Peri-equatorial Africa.pt_PT
dc.description.sponsorshipFinancial support - Instituto de Investigação Científica Bento da Rocha Cabralpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAfri Health Sci. 2021;21(4):1669-76. doi: org/10.4314/ahs.v21i4.21pt_PT
dc.identifier.doi10.4314/ahs.v21i4.21pt_PT
dc.identifier.eissn1680-6905
dc.identifier.urihttp://hdl.handle.net/10400.18/7917
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMakerere University Medical School (Uganda)pt_PT
dc.relation.publisherversionhttps://www.ajol.info/index.php/ahs/article/view/218917pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBlood Pressurept_PT
dc.subjectGeneticspt_PT
dc.subjectAfricapt_PT
dc.subjectG6PDpt_PT
dc.subjectCYB5R3pt_PT
dc.subjectDoenças Genéticaspt_PT
dc.subjectHipertensãopt_PT
dc.subjectModificadores Genéticospt_PT
dc.subjectHBApt_PT
dc.subjectAlfa-talassémiapt_PT
dc.titleDifferences in the genotype frequencies of genes related to blood pressure regulation - a comparative study between South-West Europe and Peri-equatorial Africapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1676pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage1669pt_PT
oaire.citation.titleAfrican Health Sciencespt_PT
oaire.citation.volume21pt_PT
person.familyNameFaustino
person.givenNamePaula
person.identifier.ciencia-idF01A-353A-433E
person.identifier.orcid0000-0002-6269-4867
person.identifier.ridM-3519-2014
person.identifier.scopus-author-id8158641100
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication94303e78-8b7d-4e24-811d-3af3b1a4e330
relation.isAuthorOfPublication.latestForDiscovery94303e78-8b7d-4e24-811d-3af3b1a4e330

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Aguiar L et al Genética populacional - Africa 2021.pdf
Size:
319.94 KB
Format:
Adobe Portable Document Format
Download

Collections

DGH - Artigos em revistas internacionais