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Serum 25-hydroxyvitamin D levels in a healthy population from the North of Portugal

2016-11-05Journal article Restricted access
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dc.contributor.authorBettencourt, Andreia
dc.contributor.authorBoleixa, Daniela
dc.contributor.authorReis, Júlia
dc.contributor.authorOliveira, José Carlos
dc.contributor.authorMendonça, Denisa
dc.contributor.authorCosta, Paulo Pinho
dc.contributor.authorSilva, Berta Martins da
dc.contributor.authorMarinho, António
dc.contributor.authorSilva, Ana Martins da
dc.date.accessioned2017-03-07T13:44:07Z
dc.date.available2021-10-06T00:30:10Z
dc.date.issued2016-11-05
dc.description.abstractVitamin D status in human populations has become a matter of great concern, in the wake of a multitude of published works that document widespread vitamin D deficiency across Europe, even in countries with abundant sunlight. In Portugal there are no measures of 25-hydroxyvitamin D - 25(OH)D - levels in the general adult population. The purpose of this study was to measure 25(OH)D levels in a healthy population cohort and investigate the possible association with season and selected demographic and laboratory measurements. A cohort of 198 participants (18-67 years) living in the north of Portugal, Porto, conducted in July and August 2015 (summer time) and April 2016 (winter time) was studied to evaluate serum 25(OH)D levels. Sociodemographic characteristics (age, sex and body mass index) and season of the year were taken into account as possible 25(OH)D levels codeterminants. In the whole group, the mean level of serum 25(OH)D was 55.4±23.4 nmol/L, with 48% of the population presenting levels compatible with vitamin D deficiency (below 50 nmol/L). In the winter period, this value reaches 74%. No statistically significant differences were observed between genders (57.4±23.9 vs. 53.3±22.8 nmol/L, p=0.219) as well as no statistically significant correlation was found between age and 25(OH)D levels (p=0.349). As expected higher levels of 25(OH)D were observed in summer than in winter (68.2±21.5 vs. 42.2±16.9 nmol/L; p<0.0001). Serum 25(OH)D levels were significantly lower in obese compared to non-obese subjects (46.6±17.6 vs. 57.7±24.2 nmol/L, p=0.012). Vitamin D deficiency is prevalent in this area, affecting almost half of the population. Body mass index and season are predictors for lower 25-hydroxyvitamin D levels and vitamin D status. An effective strategy to prevent vitamin D deficiency and insufficiency should be envisaged and implemented in our population.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Steroid Biochem Mol Biol. 2018 Jan;175:97-101. doi: 10.1016/j.jsbmb.2016.11.005. Epub 2016 Nov 5.pt_PT
dc.identifier.doi10.1016/j.jsbmb.2016.11.005pt_PT
dc.identifier.issn0960-0760
dc.identifier.urihttp://hdl.handle.net/10400.18/4535
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0960076016302989pt_PT
dc.subject25(OH)D Levelspt_PT
dc.subjectHealthy Adult Populationpt_PT
dc.subjectVitamin D Statuspt_PT
dc.subjectPortugalpt_PT
dc.subjectDoenças Genéticaspt_PT
dc.titleSerum 25-hydroxyvitamin D levels in a healthy population from the North of Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleJournal of Steroid Biochemistry and Molecular Biologypt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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