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Food Consumption Data as a Tool to Estimate Exposure to Mycoestrogens

2020-02-13Artigo científico Acesso aberto
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dc.contributor.authorMartins, Carla
dc.contributor.authorTorres, Duarte
dc.contributor.authorLopes, Carla
dc.contributor.authorCorreia, Daniela
dc.contributor.authorGoios, Ana
dc.contributor.authorAssunção, Ricardo
dc.contributor.authorAlvito, Paula
dc.contributor.authorVidal, Arnaud
dc.contributor.authorDe Boevre, M.
dc.contributor.authorDe Saeger, Sarah
dc.contributor.authorNunes, Carla
dc.date.accessioned2021-03-05T14:27:18Z
dc.date.available2021-03-05T14:27:18Z
dc.date.issued2020-02-13
dc.description.abstractZearalenone and alternariol are mycotoxins produced by Fusarium and Alternaria species, respectively, that present estrogenic activity and consequently are classified as endocrine disruptors. To estimate the exposure of the Portuguese population to these two mycotoxins at a national level, a modelling approach, based on data from 94 Portuguese volunteers, was developed considering as inputs: i) the food consumption data generated within the National Food and Physical Activity Survey; and ii) the human biomonitoring data used to assess the exposure to the referred mycotoxins. Six models of association between mycoestrogens urinary levels (zearalenone, total zearalenone and alternariol) and food items (meat, cheese, and fresh-cheese, breakfast cereals, sweets) were established. Applying the obtained models to the consumption data (n = 5811) of the general population, the median estimates of the probable daily intake revealed that a fraction of the Portuguese population might exceed the tolerable daily intake defined for zearalenone. A reference intake value for alternariol is still lacking, thus the characterization of risk due to the exposure to this mycotoxin was not possible to perform. Although the unavoidable uncertainties, these results are important contributions to understand the exposure to endocrine disruptors in Portugal and the potential Public Health consequences.pt_PT
dc.description.sponsorshipThanks are due to FCT/MCTES for the financial support to CESAM (UID/AMB/50017/2019), through national funds. This research was also supported by the project MYTOX-SOUTH, Ghent University Global Minds program, and the IAN-AF survey funded by the EEA Grants Program, Public Health Initiatives (PT06-000088SI3).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationToxins (Basel). 2020 Feb 13;12(2):118. doi: 10.3390/toxins12020118pt_PT
dc.identifier.doi10.3390/toxins12020118pt_PT
dc.identifier.issn2072-6651
dc.identifier.urihttp://hdl.handle.net/10400.18/7327
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2072-6651/12/2/118pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMycotoxinspt_PT
dc.subjectFood Consumptionpt_PT
dc.subjectUrinary Biomarkerspt_PT
dc.subjectPublic Healthpt_PT
dc.subjectToxicologiapt_PT
dc.subjectAvaliação do Riscopt_PT
dc.subjectSegurança Alimentarpt_PT
dc.titleFood Consumption Data as a Tool to Estimate Exposure to Mycoestrogenspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAMB%2F50017%2F2013/PT (2019)
oaire.citation.issue2pt_PT
oaire.citation.startPage118pt_PT
oaire.citation.titleToxinspt_PT
oaire.citation.volume12pt_PT
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com página web do editor da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationf076fef9-580b-485a-9a0e-c5a599424c6e
relation.isProjectOfPublication.latestForDiscoveryf076fef9-580b-485a-9a0e-c5a599424c6e

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