Posttranscriptional Regulation and RNA Binding Proteins in Cancer Biology

Ghigna, Claudia; Cartegni, Luca; Jordan, Peter; Paronetto, Maria Paola

http://hdl.handle.net/10400.18/3401

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Authors

Ghigna, Claudia

Cartegni, Luca

Jordan, Peter

Paronetto, Maria Paola

Abstract(s)

Following the completion of the human genome sequence and the concomitant technological innovations required for whole genome analyses, the last decade has witnessed an explosion of data and information concerning the posttranscriptional regulation of gene expression, in both pathological and nonpathological contexts. Among the most notable posttranscriptional events studied are the widespread usage of alternative splicing, the pleiotropic regulatory roles of miRNAs, and breakthroughs in the understanding of the control of gene expression by noncoding RNA transcripts. In this special issue of this journal, the spotlight is centered on the role that various mechanisms of posttranscriptional regulation—and the RNA binding proteins (RBPs) that control them—play in cancer biology.