Publicação
Diagnostic algorithms for tuberculosis in Europe: insights from the European Reference Laboratory Network for Tuberculosis (ERLTB-Net)
| dc.contributor.author | Saluzzo, Francesca | |
| dc.contributor.author | Cabibbe, Andrea Maurizio | |
| dc.contributor.author | Anthony, Richard | |
| dc.contributor.author | Aubry, Alexandra | |
| dc.contributor.author | Drobniewski, Francis | |
| dc.contributor.author | Holicka, Yen | |
| dc.contributor.author | Lillebaek, Troels | |
| dc.contributor.author | Macedo, Rita | |
| dc.contributor.author | Mansjö, Mikael | |
| dc.contributor.author | Szél, Viktoria | |
| dc.contributor.author | Žmak, Ljiljana | |
| dc.contributor.author | Cirillo, Daniela M. | |
| dc.contributor.author | Groenheit, Ramona | |
| dc.date.accessioned | 2026-02-20T11:53:18Z | |
| dc.date.available | 2026-02-20T11:53:18Z | |
| dc.date.issued | 2025-11-15 | |
| dc.description.abstract | The reported poor treatment outcomes for extensively drug-resistant tuberculosis (TB) in the European region highlight the urgent need for effective and context-appropriate diagnostic strategies. While the World Health Organisation (WHO) provides model algorithms, these require adaptation to the European Union/European Economic Area (EU/EEA) context, a setting with low TB incidence but high resources. This viewpoint from the European Reference Laboratory Network for TB (ERLTB-Net) proposes a tailored diagnostic algorithm that prioritises the universal use of WHO-recommended molecular rapid diagnostic tests, systematic culture, and whole genome sequencing (WGS). This approach integrates phenotypic drug susceptibility testing strategically and outlines the possible role of targeted next-generation sequencing (tNGS) in the EU/EEA setting. The algorithm also addresses the importance of diagnostic harmonisation, cross-border collaboration, and sustained investment in sequencing capacity. By aligning diagnostic practices with the regional epidemiology and laboratory infrastructure, this stepwise, resource-sensitive approach aims to strengthen TB control, improve treatment outcomes, and guide public health action in the EU/EEA. | eng |
| dc.description.sponsorship | The authors are thankful for the support from the European Centre for Disease Prevention and Control (ECDC) through the 3rd European Reference Laboratory Network for Tuberculosis (ERLTB-Net-3) funding infrastructure (ECDC/GRANT/2022/010). | |
| dc.identifier.citation | Lancet Reg Health Eur. 2025 Nov 15:60:101516. doi: 10.1016/j.lanepe.2025.101516. eCollection 2026 Jan | |
| dc.identifier.doi | 10.1016/j.lanepe.2025.101516 | |
| dc.identifier.eissn | 2666-7762 | |
| dc.identifier.pmid | 41323364 | |
| dc.identifier.uri | http://hdl.handle.net/10400.18/10960 | |
| dc.language.iso | en | |
| dc.peerreviewed | yes | |
| dc.publisher | Elsevier | |
| dc.relation.hasversion | https://www.sciencedirect.com/science/article/pii/S2666776225003084?via%3Dihub | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | Tuberculosis | |
| dc.subject | Diagnostic Algorithms | |
| dc.subject | Drug Resistance | |
| dc.subject | EU/EEA | |
| dc.subject | Whole-genome Sequencing | |
| dc.subject | Europe | |
| dc.subject | Infecções Respiratórias | |
| dc.subject | Resistência aos Antimicrobianos | |
| dc.title | Diagnostic algorithms for tuberculosis in Europe: insights from the European Reference Laboratory Network for Tuberculosis (ERLTB-Net) | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.startPage | 101516 | |
| oaire.citation.title | The Lancet Regional Health Europe | |
| oaire.citation.volume | 60 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 |