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Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease

2017-01-04Journal article Open access
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dc.contributor.authorCosta Pereira, Cristiana
dc.contributor.authorDurães, Cecília
dc.contributor.authorCoelho, Rosa
dc.contributor.authorGrácio, Daniela
dc.contributor.authorSilva, Marco
dc.contributor.authorPeixoto, Armando
dc.contributor.authorLago, Paula
dc.contributor.authorPereira, Márcia
dc.contributor.authorCatarino, Telmo
dc.contributor.authorPinho, Salomé
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorMacedo, Guilherme
dc.contributor.authorAnnese, Vito
dc.contributor.authorMagro, Fernando
dc.date.accessioned2018-03-22T15:36:44Z
dc.date.available2018-03-22T15:36:44Z
dc.date.issued2017-01-04
dc.description.abstractInflammation is the driving force in inflammatory bowel disease (IBD) and its link to oxidative stress and carcinogenesis has long been accepted. The antioxidant system of the intestinal mucosa in IBD is compromised resulting in increased oxidative injury. This defective antioxidant system may be the result of genetic variants in antioxidant genes, which can represent susceptibility factors for IBD, namely Crohn's disease (CD) and ulcerative colitis (UC). Single nucleotide polymorphisms (SNPs) in the antioxidant genes SOD2 (rs4880) and GPX1 (rs1050450) were genotyped in a Portuguese population comprising 436 Crohn's disease and 367 ulcerative colitis patients, and 434 healthy controls. We found that the AA genotype in GPX1 is associated with ulcerative colitis (OR = 1.93, adjusted P-value = 0.037). Moreover, we found nominal significant associations between SOD2 and Crohn's disease susceptibility and disease subphenotypes but these did not withstand the correction for multiple testing. These findings indicate a possible link between disease phenotypes and antioxidant genes. These results suggest a potential role for antioxidant genes in IBD pathogenesis and should be considered in future association studies.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPLoS One. 2017 Jan 4;12(1):e0169102. doi: 10.1371/journal.pone.0169102. eCollection 2017pt_PT
dc.identifier.doi10.1371/journal.pone.0169102pt_PT
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10400.18/5429
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPublic Library of Sciencept_PT
dc.relation.publisherversionhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0169102pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAdultpt_PT
dc.subjectAgedpt_PT
dc.subjectColitis, Ulcerativept_PT
dc.subjectCrohn Diseasept_PT
dc.subjectFemalept_PT
dc.subjectGenetic Predisposition to Diseasept_PT
dc.subjectGenotypept_PT
dc.subjectGlutathione Peroxidasept_PT
dc.subjectHumanspt_PT
dc.subjectInflammatory Bowel Diseasespt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectPolymorphism, Single Nucleotidept_PT
dc.subjectSuperoxide Dismutasept_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleAssociation between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Diseasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.startPagee0169102pt_PT
oaire.citation.titlePLoS Onept_PT
oaire.citation.volume12pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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