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Cytokine gene polymorphisms in Pigeon Breeder's Disease expression

2020-09-30Journal article Restricted access
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dc.contributor.authorFreitas, Cláudia
dc.contributor.authorLima, Bruno
dc.contributor.authorMartins, Natália
dc.contributor.authorMelo, Natália
dc.contributor.authorMota, Patrícia
dc.contributor.authorNovais-Bastos, Hélder
dc.contributor.authorAlves, Helena
dc.contributor.authorSokhatska, Oksana
dc.contributor.authorDelgado, Luís
dc.contributor.authorMorais, António
dc.date.accessioned2021-04-08T11:24:39Z
dc.date.available2021-04-08T11:24:39Z
dc.date.issued2020-09-30
dc.description.abstractBackground: Exaggerated immunological response to repeated inhalation of organic or chemical dusts may lead to Hypersensitivity Pneumonitis among sensitized individuals. Only a few exposed individuals became ill and disease expression pattern is highly variable which suggest that genetic factors may play a role. Aim: To investigate interferon (IFN)-γ, tumour necrosis factor (TNF)-α, interleukin (IL)-6, transforming growth factor (TGF)-ß, and IL-10 gene polymorphisms in a cohort of pigeon breeder's disease (PBD) patients in comparison with exposed but healthy controls and the association with different patterns of disease. Methods: We evaluated 40 PBD patients and 70 exposed controls. IFN-γ, TNF-α, IL-6, TGF-ß, and IL-10 polymorphisms were determined by polymerase chain reaction-sequence specific primer amplification. Results: Polymorphism analysis of IFN-γ, TNF-α, IL-6, TGF-ß, and IL-10 genotypes and allele frequencies showed no differences between patients and controls. IFN-γ T/T genotype frequency was increased among patients with chronic presentation (RR=2.33, p=0.047) compared with those with acute/subacute presentation. Also, chronic presenting patients had an increased frequency of IFN-γ T allele (50% vs 22.5%, RR=1.76, p=0.011). No differences were found in TNF-α, IL-6, TGF-ß, and IL-10 genotypes neither allelic frequencies between both groups of patients. IL-6 C/C genotype was more frequent in patients who showed chronic evolution (RR=2.54, p=0.017), when comparing with patients with disease resolution. Conclusion: IFN-γ T/T and the IL-6 C/C genotypes seem to play a role in HP expression due to avian exposure, as their frequencies are increased in chronic presentations or in those with chronic evolution one year after the initial diagnosis, respectively. (Sarcoidosis Vasc Diffuse Lung Dis 2020; 37 (3): e2020004).pt_PT
dc.description.sponsorshipN. Martins would like to thank the Portuguese Foundation for Science and Technology (FCT-Portugal) for the Strategic project ref. UID/BIM/04293/2013 and “NORTE2020 - Northern Regional Operational Program” (NORTE-01-0145-FEDER-000012) and the Horizon 2020 Program (PTDC/PSI‐GER/28076/2017).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSSarcoidosis Vasc Diffuse Lung Dis. 2020;37(3):e2020004. doi: 10.36141/svdld.v37i3.9342. Epub 2020 Sep 30.pt_PT
dc.identifier.doi10.36141/svdld.v37i3.9342pt_PT
dc.identifier.issn2532-179X
dc.identifier.urihttp://hdl.handle.net/10400.18/7672
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMattioli 1885/ WASOGpt_PT
dc.relationPTDC/PSI‐GER/28076/2017pt_PT
dc.relation.publisherversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690056/pt_PT
dc.subjectPigeon breeder’s Diseasept_PT
dc.subjectHypersensitivity pneumonitispt_PT
dc.subjectCytokinespt_PT
dc.subjectGenetic Polimorphismspt_PT
dc.titleCytokine gene polymorphisms in Pigeon Breeder's Disease expressionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F04293%2F2013/PT
oaire.citation.issue3pt_PT
oaire.citation.startPagee2020004pt_PT
oaire.citation.titleSarcoidosis Vasculitis and Diffuse Lung Diseasept_PT
oaire.citation.volume37pt_PT
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationfa9009ed-65e1-4108-bd20-1304211124ea
relation.isProjectOfPublication.latestForDiscoveryfa9009ed-65e1-4108-bd20-1304211124ea

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