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Human Exposure to Disinfection By-Products in Indoor Swimming Pools: Looking at the Genotoxic Effects

2018-09-02Conference object Restricted access
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dc.contributor.authorEsteves, Filipa
dc.contributor.authorAmaro, Raquel
dc.contributor.authorSilva, Susana
dc.contributor.authorCosta, Carla
dc.contributor.authorCosta, Solange
dc.contributor.authorTeixeira, João Paulo
dc.date.accessioned2019-03-06T15:59:57Z
dc.date.available2019-03-06T15:59:57Z
dc.date.issued2018-09-02
dc.description.abstractDisinfection of pool water is an extremely important process that ensures the safety of its use avoiding water-borne infections caused by microbial pathogens. However, the chlorine used as disinfectant, in the presence of organic matter, may generate disinfection by-products (DBPs), including trihalomethanes (THMs), a class that includes genotoxic compounds, which are inhaled and absorbed by the skin. Previous studies have shown that exposure to these DBPs are associated with adverse health outcomes. The aim of this study was to assess DNA damage in swimming pool users exposed to THMs. To evaluate DNA damage, blood samples were collected from a group of approximately 150 swimmers in different indoor chlorinated pools located in north of Portugal. Levels of DNA strand breaks and oxidized purines (formamidopyrimidine DNA glycolase) sites were determined in lymphocytes using the comet assay. Individual exposure to THMs compounds was analysed using a predictive model; analysis included not only total THMs but also chloroform, dibromochloromethane, bromochloromethane and bromoform separately. Data obtained will increase knowledge on the potential genotoxic risks associated to THMs exposure in indoor swimming pools. Furthermore, results may be useful to perform a human health risk assessment model essential for development of risk management strategies.pt_PT
dc.description.sponsorshipThis work was supported by Project NORTE-01-0145-FEDER-000010 - Health, Comfort and Energy in the Built Environment (HEBE), cofinanced by Programa Operacional Regional do Norte (NORTE2020), through Fundo Europeu de Desenvolvimento Regional (FEDER).pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/6077
dc.language.isoengpt_PT
dc.subjectDNA Damagept_PT
dc.subjectSwimming Poolpt_PT
dc.subjectTrihalomethanespt_PT
dc.subjectExposition to THMspt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleHuman Exposure to Disinfection By-Products in Indoor Swimming Pools: Looking at the Genotoxic Effectspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceBrussels, Belgiumpt_PT
oaire.citation.title4th Congress of the European Societies of Toxicology (EUROTOX 2018), 2-5 September 2018pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typeconferenceObjectpt_PT

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